A0A224AV41 · A0A224AV41_HUMAN
- ProteinAdenomatous polyposis coli protein isoform t
- GeneAPC
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2853 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | beta-catenin destruction complex | |
Cellular Component | catenin complex | |
Cellular Component | cytoplasmic microtubule | |
Cellular Component | intracellular membrane-bounded organelle | |
Molecular Function | beta-catenin binding | |
Molecular Function | gamma-catenin binding | |
Molecular Function | microtubule binding | |
Biological Process | cell fate specification | |
Biological Process | cell migration | |
Biological Process | negative regulation of canonical Wnt signaling pathway | |
Biological Process | negative regulation of microtubule depolymerization | |
Biological Process | nervous system development | |
Biological Process | pattern specification process | |
Biological Process | positive regulation of protein catabolic process | |
Biological Process | regulation of cell differentiation | |
Biological Process | Wnt signaling pathway |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A224AV41
Subcellular Location
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, coiled coil, repeat, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 23-45 | Polar residues | ||||
Sequence: GSWSTGGSRSCVRQETKSPGGAR | ||||||
Region | 23-48 | Disordered | ||||
Sequence: GSWSTGGSRSCVRQETKSPGGARTSG | ||||||
Coiled coil | 144-178 | |||||
Sequence: LEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKR | ||||||
Region | 249-315 | Disordered | ||||
Sequence: ATEAERSSQNKHETGSHDAERQNEGQGVGEINMATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLT | ||||||
Compositional bias | 254-272 | Basic and acidic residues | ||||
Sequence: RSSQNKHETGSHDAERQNE | ||||||
Compositional bias | 276-314 | Polar residues | ||||
Sequence: VGEINMATSGNGQGSTTRMDHETASVLSSSSTHSAPRRL | ||||||
Repeat | 670-712 | ARM | ||||
Sequence: NCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMG | ||||||
Region | 838-888 | Disordered | ||||
Sequence: TTVLPSSSSSRGSLDSSRSEKDRSLERERGIGLGNYHPATENPGTSSKRGL | ||||||
Compositional bias | 852-867 | Basic and acidic residues | ||||
Sequence: DSSRSEKDRSLERERG | ||||||
Region | 933-953 | Disordered | ||||
Sequence: RRSSAAHTHSNTYNFTKSENS | ||||||
Compositional bias | 936-953 | Polar residues | ||||
Sequence: SAAHTHSNTYNFTKSENS | ||||||
Compositional bias | 968-985 | Polar residues | ||||
Sequence: RSSNDSLNSVSSSDGYGK | ||||||
Region | 968-997 | Disordered | ||||
Sequence: RSSNDSLNSVSSSDGYGKRGQMKPSIESYS | ||||||
Region | 1109-1179 | Disordered | ||||
Sequence: VSPYRSRGANGSETNRVGSNHGINQNVSQSLCQEDDYEDDKPTNYSERYSEEEQHEEEERPTNYSIKYNEE | ||||||
Compositional bias | 1111-1140 | Polar residues | ||||
Sequence: PYRSRGANGSETNRVGSNHGINQNVSQSLC | ||||||
Compositional bias | 1142-1179 | Basic and acidic residues | ||||
Sequence: EDDYEDDKPTNYSERYSEEEQHEEEERPTNYSIKYNEE | ||||||
Region | 1200-1254 | Disordered | ||||
Sequence: SQKQSFSFSKSSSGQSSKTEHMSSSSENTSTPSSNAKRQNQLHPSSAQSRSGQPQ | ||||||
Region | 1321-1386 | Disordered | ||||
Sequence: IGTRSAEDPVSEVPAVSQHPRTKSSRLQGSSLSSESARHKAVEFSSGAKSPSKSGAQTPKSPPEHY | ||||||
Compositional bias | 1337-1360 | Polar residues | ||||
Sequence: SQHPRTKSSRLQGSSLSSESARHK | ||||||
Compositional bias | 1367-1384 | Polar residues | ||||
Sequence: GAKSPSKSGAQTPKSPPE | ||||||
Region | 1413-1485 | Disordered | ||||
Sequence: SSVQSEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPPPPPQTAQTKREVPKNKAPTAEKRESGPKQAAVNAA | ||||||
Compositional bias | 1443-1457 | Pro residues | ||||
Sequence: PSRSKTPPPPPQTAQ | ||||||
Region | 1536-1579 | Disordered | ||||
Sequence: PPVQENDNGNETESEQPKESNENQEKEAEKTIDSEKDLLDDSDD | ||||||
Compositional bias | 1546-1572 | Basic and acidic residues | ||||
Sequence: ETESEQPKESNENQEKEAEKTIDSEKD | ||||||
Region | 1593-1621 | Disordered | ||||
Sequence: MPTKSSRKAKKPAQTASKLPPPVARKPSQ | ||||||
Region | 1673-1727 | Disordered | ||||
Sequence: ESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQGGKTSSVTIPELDDNK | ||||||
Compositional bias | 1690-1704 | Basic and acidic residues | ||||
Sequence: QSGEFEKRDTIPTEG | ||||||
Compositional bias | 1705-1722 | Polar residues | ||||
Sequence: RSTDEAQGGKTSSVTIPE | ||||||
Region | 1739-1862 | Disordered | ||||
Sequence: NSAMPKGKSHKPFRVKKIMDQVQQASASSSAPNKNQLDGKKKKPTSPVKPIPQNTEYRTRVRKNADSKNNLNAERVFSDNKDSKKQNLKNNSKDFNDKLPNNEDRVRGSFAFDSPHHYTPIEGT | ||||||
Compositional bias | 1759-1773 | Polar residues | ||||
Sequence: QVQQASASSSAPNKN | ||||||
Compositional bias | 1797-1842 | Basic and acidic residues | ||||
Sequence: TRVRKNADSKNNLNAERVFSDNKDSKKQNLKNNSKDFNDKLPNNED | ||||||
Compositional bias | 1888-1905 | Basic and acidic residues | ||||
Sequence: KAELRKAKENKESEAKVT | ||||||
Region | 1888-1962 | Disordered | ||||
Sequence: KAELRKAKENKESEAKVTSHTELTSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSKDIPDRGAATDEKLQ | ||||||
Compositional bias | 1906-1948 | Polar residues | ||||
Sequence: SHTELTSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSK | ||||||
Region | 1975-2021 | Disordered | ||||
Sequence: HNSSLSSLSDIDQENNNKENEPIKETEPPDSQGEPSKPQASGYAPKS | ||||||
Compositional bias | 1988-2005 | Basic and acidic residues | ||||
Sequence: ENNNKENEPIKETEPPDS | ||||||
Region | 2053-2082 | Disordered | ||||
Sequence: ISSAMPKKKKPSRLKGDNEKHSPRNMGGIL | ||||||
Region | 2157-2645 | Disordered | ||||
Sequence: PFHLTPDQEEKPFTSNKGPRILKPGEKSTLETKKIESESKGIKGGKKVYKSLITGKVRSNSEISGQMKQPLQANMPSISRGRTMIHIPGVRNSSSSTSPVSKKGPPLKTPASKSPSEGQTATTSPRGAKPSVKSELSPVARQTSQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKGLNQMNNGNGANKKVELSRMSSTKSSGSESDRSERPVLVRQSTFIKEAPSPTLRRKLEESASFESLSPSSRPASPTRSQAQTPVLSPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEYNDGRPAKRHDIARSHSESPSRLPINRSGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASSESSEKAKSEDEKHVNSISGTKQSKENQVSAKGTWRKIKENEFSPTNSTSQTVSSGAT | ||||||
Compositional bias | 2180-2201 | Basic and acidic residues | ||||
Sequence: PGEKSTLETKKIESESKGIKGG | ||||||
Compositional bias | 2210-2235 | Polar residues | ||||
Sequence: TGKVRSNSEISGQMKQPLQANMPSIS | ||||||
Domain | 2234-2585 | Adenomatous polyposis coli protein basic | ||||
Sequence: ISRGRTMIHIPGVRNSSSSTSPVSKKGPPLKTPASKSPSEGQTATTSPRGAKPSVKSELSPVARQTSQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKGLNQMNNGNGANKKVELSRMSSTKSSGSESDRSERPVLVRQSTFIKEAPSPTLRRKLEESASFESLSPSSRPASPTRSQAQTPVLSPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEYNDGRPAKRHDIARSHSESPSRLPINRSGTWKREHSKHSSSLPRVSTWRRTGSSSSILS | ||||||
Compositional bias | 2244-2259 | Polar residues | ||||
Sequence: PGVRNSSSSTSPVSKK | ||||||
Compositional bias | 2268-2436 | Polar residues | ||||
Sequence: SKSPSEGQTATTSPRGAKPSVKSELSPVARQTSQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKGLNQMNNGNGANKKVELSRMSSTKSSG | ||||||
Compositional bias | 2471-2511 | Polar residues | ||||
Sequence: SFESLSPSSRPASPTRSQAQTPVLSPSLPDMSLSTHSSVQA | ||||||
Compositional bias | 2529-2543 | Basic and acidic residues | ||||
Sequence: DGRPAKRHDIARSHS | ||||||
Compositional bias | 2567-2590 | Polar residues | ||||
Sequence: SLPRVSTWRRTGSSSSILSASSES | ||||||
Compositional bias | 2591-2606 | Basic and acidic residues | ||||
Sequence: SEKAKSEDEKHVNSIS | ||||||
Compositional bias | 2627-2645 | Polar residues | ||||
Sequence: ENEFSPTNSTSQTVSSGAT | ||||||
Region | 2677-2724 | Disordered | ||||
Sequence: NNPRSGRSPTGNTPPVIDSVSEKANPNIKDSKDNQAKQNVGNGSVPMR | ||||||
Compositional bias | 2679-2696 | Polar residues | ||||
Sequence: PRSGRSPTGNTPPVIDSV | ||||||
Domain | 2680-2853 | EB-1 binding | ||||
Sequence: RSGRSPTGNTPPVIDSVSEKANPNIKDSKDNQAKQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVSETNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKTDSTESSGTQSPKRHSGSYLVTSV | ||||||
Compositional bias | 2707-2721 | Polar residues | ||||
Sequence: SKDNQAKQNVGNGSV | ||||||
Region | 2739-2853 | Disordered | ||||
Sequence: DAPDQKGTEIKPGQNNPVPVSETNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKTDSTESSGTQSPKRHSGSYLVTSV | ||||||
Compositional bias | 2747-2823 | Polar residues | ||||
Sequence: EIKPGQNNPVPVSETNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNT | ||||||
Compositional bias | 2833-2853 | Polar residues | ||||
Sequence: TESSGTQSPKRHSGSYLVTSV |
Sequence similarities
Belongs to the adenomatous polyposis coli (APC) family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,853
- Mass (Da)312,108
- Last updated2017-10-25 v1
- ChecksumDF339B1CA56BDF15
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 23-45 | Polar residues | ||||
Sequence: GSWSTGGSRSCVRQETKSPGGAR | ||||||
Compositional bias | 254-272 | Basic and acidic residues | ||||
Sequence: RSSQNKHETGSHDAERQNE | ||||||
Compositional bias | 276-314 | Polar residues | ||||
Sequence: VGEINMATSGNGQGSTTRMDHETASVLSSSSTHSAPRRL | ||||||
Compositional bias | 852-867 | Basic and acidic residues | ||||
Sequence: DSSRSEKDRSLERERG | ||||||
Compositional bias | 936-953 | Polar residues | ||||
Sequence: SAAHTHSNTYNFTKSENS | ||||||
Compositional bias | 968-985 | Polar residues | ||||
Sequence: RSSNDSLNSVSSSDGYGK | ||||||
Compositional bias | 1111-1140 | Polar residues | ||||
Sequence: PYRSRGANGSETNRVGSNHGINQNVSQSLC | ||||||
Compositional bias | 1142-1179 | Basic and acidic residues | ||||
Sequence: EDDYEDDKPTNYSERYSEEEQHEEEERPTNYSIKYNEE | ||||||
Compositional bias | 1337-1360 | Polar residues | ||||
Sequence: SQHPRTKSSRLQGSSLSSESARHK | ||||||
Compositional bias | 1367-1384 | Polar residues | ||||
Sequence: GAKSPSKSGAQTPKSPPE | ||||||
Compositional bias | 1443-1457 | Pro residues | ||||
Sequence: PSRSKTPPPPPQTAQ | ||||||
Compositional bias | 1546-1572 | Basic and acidic residues | ||||
Sequence: ETESEQPKESNENQEKEAEKTIDSEKD | ||||||
Compositional bias | 1690-1704 | Basic and acidic residues | ||||
Sequence: QSGEFEKRDTIPTEG | ||||||
Compositional bias | 1705-1722 | Polar residues | ||||
Sequence: RSTDEAQGGKTSSVTIPE | ||||||
Compositional bias | 1759-1773 | Polar residues | ||||
Sequence: QVQQASASSSAPNKN | ||||||
Compositional bias | 1797-1842 | Basic and acidic residues | ||||
Sequence: TRVRKNADSKNNLNAERVFSDNKDSKKQNLKNNSKDFNDKLPNNED | ||||||
Compositional bias | 1888-1905 | Basic and acidic residues | ||||
Sequence: KAELRKAKENKESEAKVT | ||||||
Compositional bias | 1906-1948 | Polar residues | ||||
Sequence: SHTELTSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSK | ||||||
Compositional bias | 1988-2005 | Basic and acidic residues | ||||
Sequence: ENNNKENEPIKETEPPDS | ||||||
Compositional bias | 2180-2201 | Basic and acidic residues | ||||
Sequence: PGEKSTLETKKIESESKGIKGG | ||||||
Compositional bias | 2210-2235 | Polar residues | ||||
Sequence: TGKVRSNSEISGQMKQPLQANMPSIS | ||||||
Compositional bias | 2244-2259 | Polar residues | ||||
Sequence: PGVRNSSSSTSPVSKK | ||||||
Compositional bias | 2268-2436 | Polar residues | ||||
Sequence: SKSPSEGQTATTSPRGAKPSVKSELSPVARQTSQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKGLNQMNNGNGANKKVELSRMSSTKSSG | ||||||
Compositional bias | 2471-2511 | Polar residues | ||||
Sequence: SFESLSPSSRPASPTRSQAQTPVLSPSLPDMSLSTHSSVQA | ||||||
Compositional bias | 2529-2543 | Basic and acidic residues | ||||
Sequence: DGRPAKRHDIARSHS | ||||||
Compositional bias | 2567-2590 | Polar residues | ||||
Sequence: SLPRVSTWRRTGSSSSILSASSES | ||||||
Compositional bias | 2591-2606 | Basic and acidic residues | ||||
Sequence: SEKAKSEDEKHVNSIS | ||||||
Compositional bias | 2627-2645 | Polar residues | ||||
Sequence: ENEFSPTNSTSQTVSSGAT | ||||||
Compositional bias | 2679-2696 | Polar residues | ||||
Sequence: PRSGRSPTGNTPPVIDSV | ||||||
Compositional bias | 2707-2721 | Polar residues | ||||
Sequence: SKDNQAKQNVGNGSV | ||||||
Compositional bias | 2747-2823 | Polar residues | ||||
Sequence: EIKPGQNNPVPVSETNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNT | ||||||
Compositional bias | 2833-2853 | Polar residues | ||||
Sequence: TESSGTQSPKRHSGSYLVTSV |