A0A224AV41 · A0A224AV41_HUMAN

  • Protein
    Adenomatous polyposis coli protein isoform t
  • Gene
    APC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentbeta-catenin destruction complex
Cellular Componentcatenin complex
Cellular Componentcytoplasmic microtubule
Cellular Componentintracellular membrane-bounded organelle
Molecular Functionbeta-catenin binding
Molecular Functiongamma-catenin binding
Molecular Functionmicrotubule binding
Biological Processcell fate specification
Biological Processcell migration
Biological Processnegative regulation of canonical Wnt signaling pathway
Biological Processnegative regulation of microtubule depolymerization
Biological Processnervous system development
Biological Processpattern specification process
Biological Processpositive regulation of protein catabolic process
Biological Processregulation of cell differentiation
Biological ProcessWnt signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Adenomatous polyposis coli protein isoform t
    • HCG2031476, isoform CRA_d

Gene names

    • Name
      APC
    • ORF names
      hCG_2031476

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A224AV41

PTM/Processing

Proteomic databases

Family & Domains

Features

Showing features for compositional bias, region, coiled coil, repeat, domain.

TypeIDPosition(s)Description
Compositional bias23-45Polar residues
Region23-48Disordered
Coiled coil144-178
Region249-315Disordered
Compositional bias254-272Basic and acidic residues
Compositional bias276-314Polar residues
Repeat670-712ARM
Region838-888Disordered
Compositional bias852-867Basic and acidic residues
Region933-953Disordered
Compositional bias936-953Polar residues
Compositional bias968-985Polar residues
Region968-997Disordered
Region1109-1179Disordered
Compositional bias1111-1140Polar residues
Compositional bias1142-1179Basic and acidic residues
Region1200-1254Disordered
Region1321-1386Disordered
Compositional bias1337-1360Polar residues
Compositional bias1367-1384Polar residues
Region1413-1485Disordered
Compositional bias1443-1457Pro residues
Region1536-1579Disordered
Compositional bias1546-1572Basic and acidic residues
Region1593-1621Disordered
Region1673-1727Disordered
Compositional bias1690-1704Basic and acidic residues
Compositional bias1705-1722Polar residues
Region1739-1862Disordered
Compositional bias1759-1773Polar residues
Compositional bias1797-1842Basic and acidic residues
Compositional bias1888-1905Basic and acidic residues
Region1888-1962Disordered
Compositional bias1906-1948Polar residues
Region1975-2021Disordered
Compositional bias1988-2005Basic and acidic residues
Region2053-2082Disordered
Region2157-2645Disordered
Compositional bias2180-2201Basic and acidic residues
Compositional bias2210-2235Polar residues
Domain2234-2585Adenomatous polyposis coli protein basic
Compositional bias2244-2259Polar residues
Compositional bias2268-2436Polar residues
Compositional bias2471-2511Polar residues
Compositional bias2529-2543Basic and acidic residues
Compositional bias2567-2590Polar residues
Compositional bias2591-2606Basic and acidic residues
Compositional bias2627-2645Polar residues
Region2677-2724Disordered
Compositional bias2679-2696Polar residues
Domain2680-2853EB-1 binding
Compositional bias2707-2721Polar residues
Region2739-2853Disordered
Compositional bias2747-2823Polar residues
Compositional bias2833-2853Polar residues

Sequence similarities

Belongs to the adenomatous polyposis coli (APC) family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,853
  • Mass (Da)
    312,108
  • Last updated
    2017-10-25 v1
  • Checksum
    DF339B1CA56BDF15
MYASLGSGPVAPLPASVPPSVLGSWSTGGSRSCVRQETKSPGGARTSGHWASVWQEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSKMSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSLQTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEINMATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLLHGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQSLYGDYVFDTNRHDDNRSDNFNTGNMTVLSPYLNTTVLPSSSSSRGSLDSSRSEKDRSLERERGIGLGNYHPATENPGTSSKRGLQISTTAAQIAKVMEEVSAIHTSQEDRSSGSTTELHCVTDERNALRRSSAAHTHSNTYNFTKSENSNRTCSMPYAKLEYKRSSNDSLNSVSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDGELDTPINYSLKYSDEQLNSGRQSPSQNERWARPKHIIEDEIKQSEQRQSRNQSTTYPVYTESTDDKHLKFQPHFGQQECVSPYRSRGANGSETNRVGSNHGINQNVSQSLCQEDDYEDDKPTNYSERYSEEEQHEEEERPTNYSIKYNEEKRHVDQPIDYSLKYATDIPSSQKQSFSFSKSSSGQSSKTEHMSSSSENTSTPSSNAKRQNQLHPSSAQSRSGQPQKAATCKVSSINQETIQTYCVEDTPICFSRCSSLSSLSSAEDEIGCNQTTQEADSANTLQIAEIKEKIGTRSAEDPVSEVPAVSQHPRTKSSRLQGSSLSSESARHKAVEFSSGAKSPSKSGAQTPKSPPEHYVQETPLMFSRCTSVSSLDSFESRSIASSVQSEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPPPPPQTAQTKREVPKNKAPTAEKRESGPKQAAVNAAVQRVQVLPDADTLLHFATESTPDGFSCSSSLSALSLDEPFIQKDVELRIMPPVQENDNGNETESEQPKESNENQEKEAEKTIDSEKDLLDDSDDDDIEILEECIISAMPTKSSRKAKKPAQTASKLPPPVARKPSQLPVYKLLPSQNRLQPQKHVSFTPGDDMPRVYCVEGTPINFSTATSLSDLTIESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQGGKTSSVTIPELDDNKAEEGDILAECINSAMPKGKSHKPFRVKKIMDQVQQASASSSAPNKNQLDGKKKKPTSPVKPIPQNTEYRTRVRKNADSKNNLNAERVFSDNKDSKKQNLKNNSKDFNDKLPNNEDRVRGSFAFDSPHHYTPIEGTPYCFSRNDSLSSLDFDDDDVDLSREKAELRKAKENKESEAKVTSHTELTSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSKDIPDRGAATDEKLQNFAIENTPVCFSHNSSLSSLSDIDQENNNKENEPIKETEPPDSQGEPSKPQASGYAPKSFHVEDTPVCFSRNSSLSSLSIDSEDDLLQECISSAMPKKKKPSRLKGDNEKHSPRNMGGILGEDLTLDLKDIQRPDSEHGLSPDSENFDWKAIQEGANSIVSSLHQAAAAACLSRQASSDSDSILSLKSGISLGSPFHLTPDQEEKPFTSNKGPRILKPGEKSTLETKKIESESKGIKGGKKVYKSLITGKVRSNSEISGQMKQPLQANMPSISRGRTMIHIPGVRNSSSSTSPVSKKGPPLKTPASKSPSEGQTATTSPRGAKPSVKSELSPVARQTSQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKGLNQMNNGNGANKKVELSRMSSTKSSGSESDRSERPVLVRQSTFIKEAPSPTLRRKLEESASFESLSPSSRPASPTRSQAQTPVLSPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEYNDGRPAKRHDIARSHSESPSRLPINRSGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASSESSEKAKSEDEKHVNSISGTKQSKENQVSAKGTWRKIKENEFSPTNSTSQTVSSGATNGAESKTLIYQMAPAVSKTEDVWVRIEDCPINNPRSGRSPTGNTPPVIDSVSEKANPNIKDSKDNQAKQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVSETNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKTDSTESSGTQSPKRHSGSYLVTSV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias23-45Polar residues
Compositional bias254-272Basic and acidic residues
Compositional bias276-314Polar residues
Compositional bias852-867Basic and acidic residues
Compositional bias936-953Polar residues
Compositional bias968-985Polar residues
Compositional bias1111-1140Polar residues
Compositional bias1142-1179Basic and acidic residues
Compositional bias1337-1360Polar residues
Compositional bias1367-1384Polar residues
Compositional bias1443-1457Pro residues
Compositional bias1546-1572Basic and acidic residues
Compositional bias1690-1704Basic and acidic residues
Compositional bias1705-1722Polar residues
Compositional bias1759-1773Polar residues
Compositional bias1797-1842Basic and acidic residues
Compositional bias1888-1905Basic and acidic residues
Compositional bias1906-1948Polar residues
Compositional bias1988-2005Basic and acidic residues
Compositional bias2180-2201Basic and acidic residues
Compositional bias2210-2235Polar residues
Compositional bias2244-2259Polar residues
Compositional bias2268-2436Polar residues
Compositional bias2471-2511Polar residues
Compositional bias2529-2543Basic and acidic residues
Compositional bias2567-2590Polar residues
Compositional bias2591-2606Basic and acidic residues
Compositional bias2627-2645Polar residues
Compositional bias2679-2696Polar residues
Compositional bias2707-2721Polar residues
Compositional bias2747-2823Polar residues
Compositional bias2833-2853Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LC085428
EMBL· GenBank· DDBJ
BBA21112.1
EMBL· GenBank· DDBJ
mRNA
CH471086
EMBL· GenBank· DDBJ
EAW49005.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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