A0A224ANK2 · A0A224ANK2_HUMAN

  • Protein
    Adenomatous polyposis coli protein isoform b
  • Gene
    APC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    2/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell periphery
Cellular Componentintracellular membrane-bounded organelle
Molecular Functionbeta-catenin binding
Molecular Functionmicrotubule binding
Biological Processnegative regulation of Wnt signaling pathway
Biological ProcessWnt signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Adenomatous polyposis coli protein isoform b

Gene names

    • Name
      APC

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A224ANK2

PTM/Processing

Proteomic databases

Structure

3D structure databases

Family & Domains

Features

Showing features for domain, coiled coil, region, compositional bias, repeat.

TypeIDPosition(s)Description
Domain4-55Adenomatous polyposis coli N-terminal dimerisation
Coiled coil6-54
Coiled coil134-168
Region239-305Disordered
Compositional bias244-262Basic and acidic residues
Compositional bias266-304Polar residues
Repeat660-702ARM
Region828-878Disordered
Compositional bias842-857Basic and acidic residues
Region923-943Disordered
Compositional bias926-943Polar residues
Compositional bias958-975Polar residues
Region958-987Disordered
Region1099-1169Disordered
Compositional bias1101-1130Polar residues
Compositional bias1132-1169Basic and acidic residues
Region1190-1244Disordered
Region1311-1376Disordered
Compositional bias1327-1350Polar residues
Compositional bias1357-1374Polar residues
Region1403-1475Disordered
Compositional bias1433-1447Pro residues
Region1526-1569Disordered
Compositional bias1536-1562Basic and acidic residues
Region1583-1611Disordered
Region1663-1717Disordered
Compositional bias1680-1694Basic and acidic residues
Compositional bias1695-1712Polar residues
Region1729-1852Disordered
Compositional bias1749-1763Polar residues
Compositional bias1787-1832Basic and acidic residues
Compositional bias1878-1895Basic and acidic residues
Region1878-1952Disordered
Compositional bias1896-1938Polar residues
Region1965-2011Disordered
Compositional bias1978-1995Basic and acidic residues
Region2043-2072Disordered
Region2147-2635Disordered
Compositional bias2170-2191Basic and acidic residues
Compositional bias2200-2225Polar residues
Domain2224-2575Adenomatous polyposis coli protein basic
Compositional bias2234-2249Polar residues
Compositional bias2258-2426Polar residues
Compositional bias2461-2501Polar residues
Compositional bias2519-2533Basic and acidic residues
Compositional bias2557-2580Polar residues
Compositional bias2581-2596Basic and acidic residues
Compositional bias2617-2635Polar residues
Region2667-2714Disordered
Compositional bias2669-2686Polar residues
Domain2670-2843EB-1 binding
Compositional bias2697-2711Polar residues
Region2729-2843Disordered
Compositional bias2737-2813Polar residues
Compositional bias2823-2843Polar residues

Sequence similarities

Belongs to the adenomatous polyposis coli (APC) family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,843
  • Mass (Da)
    311,662
  • Last updated
    2017-10-25 v1
  • Checksum
    2079F4AE4A90A281
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSKMSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSLQTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEINMATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLLHGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQSLYGDYVFDTNRHDDNRSDNFNTGNMTVLSPYLNTTVLPSSSSSRGSLDSSRSEKDRSLERERGIGLGNYHPATENPGTSSKRGLQISTTAAQIAKVMEEVSAIHTSQEDRSSGSTTELHCVTDERNALRRSSAAHTHSNTYNFTKSENSNRTCSMPYAKLEYKRSSNDSLNSVSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDGELDTPINYSLKYSDEQLNSGRQSPSQNERWARPKHIIEDEIKQSEQRQSRNQSTTYPVYTESTDDKHLKFQPHFGQQECVSPYRSRGANGSETNRVGSNHGINQNVSQSLCQEDDYEDDKPTNYSERYSEEEQHEEEERPTNYSIKYNEEKRHVDQPIDYSLKYATDIPSSQKQSFSFSKSSSGQSSKTEHMSSSSENTSTPSSNAKRQNQLHPSSAQSRSGQPQKAATCKVSSINQETIQTYCVEDTPICFSRCSSLSSLSSAEDEIGCNQTTQEADSANTLQIAEIKEKIGTRSAEDPVSEVPAVSQHPRTKSSRLQGSSLSSESARHKAVEFSSGAKSPSKSGAQTPKSPPEHYVQETPLMFSRCTSVSSLDSFESRSIASSVQSEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPPPPPQTAQTKREVPKNKAPTAEKRESGPKQAAVNAAVQRVQVLPDADTLLHFATESTPDGFSCSSSLSALSLDEPFIQKDVELRIMPPVQENDNGNETESEQPKESNENQEKEAEKTIDSEKDLLDDSDDDDIEILEECIISAMPTKSSRKAKKPAQTASKLPPPVARKPSQLPVYKLLPSQNRLQPQKHVSFTPGDDMPRVYCVEGTPINFSTATSLSDLTIESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQGGKTSSVTIPELDDNKAEEGDILAECINSAMPKGKSHKPFRVKKIMDQVQQASASSSAPNKNQLDGKKKKPTSPVKPIPQNTEYRTRVRKNADSKNNLNAERVFSDNKDSKKQNLKNNSKDFNDKLPNNEDRVRGSFAFDSPHHYTPIEGTPYCFSRNDSLSSLDFDDDDVDLSREKAELRKAKENKESEAKVTSHTELTSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSKDIPDRGAATDEKLQNFAIENTPVCFSHNSSLSSLSDIDQENNNKENEPIKETEPPDSQGEPSKPQASGYAPKSFHVEDTPVCFSRNSSLSSLSIDSEDDLLQECISSAMPKKKKPSRLKGDNEKHSPRNMGGILGEDLTLDLKDIQRPDSEHGLSPDSENFDWKAIQEGANSIVSSLHQAAAAACLSRQASSDSDSILSLKSGISLGSPFHLTPDQEEKPFTSNKGPRILKPGEKSTLETKKIESESKGIKGGKKVYKSLITGKVRSNSEISGQMKQPLQANMPSISRGRTMIHIPGVRNSSSSTSPVSKKGPPLKTPASKSPSEGQTATTSPRGAKPSVKSELSPVARQTSQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKGLNQMNNGNGANKKVELSRMSSTKSSGSESDRSERPVLVRQSTFIKEAPSPTLRRKLEESASFESLSPSSRPASPTRSQAQTPVLSPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEYNDGRPAKRHDIARSHSESPSRLPINRSGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASSESSEKAKSEDEKHVNSISGTKQSKENQVSAKGTWRKIKENEFSPTNSTSQTVSSGATNGAESKTLIYQMAPAVSKTEDVWVRIEDCPINNPRSGRSPTGNTPPVIDSVSEKANPNIKDSKDNQAKQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVSETNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKTDSTESSGTQSPKRHSGSYLVTSV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias244-262Basic and acidic residues
Compositional bias266-304Polar residues
Compositional bias842-857Basic and acidic residues
Compositional bias926-943Polar residues
Compositional bias958-975Polar residues
Compositional bias1101-1130Polar residues
Compositional bias1132-1169Basic and acidic residues
Compositional bias1327-1350Polar residues
Compositional bias1357-1374Polar residues
Compositional bias1433-1447Pro residues
Compositional bias1536-1562Basic and acidic residues
Compositional bias1680-1694Basic and acidic residues
Compositional bias1695-1712Polar residues
Compositional bias1749-1763Polar residues
Compositional bias1787-1832Basic and acidic residues
Compositional bias1878-1895Basic and acidic residues
Compositional bias1896-1938Polar residues
Compositional bias1978-1995Basic and acidic residues
Compositional bias2170-2191Basic and acidic residues
Compositional bias2200-2225Polar residues
Compositional bias2234-2249Polar residues
Compositional bias2258-2426Polar residues
Compositional bias2461-2501Polar residues
Compositional bias2519-2533Basic and acidic residues
Compositional bias2557-2580Polar residues
Compositional bias2581-2596Basic and acidic residues
Compositional bias2617-2635Polar residues
Compositional bias2669-2686Polar residues
Compositional bias2697-2711Polar residues
Compositional bias2737-2813Polar residues
Compositional bias2823-2843Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LC085427
EMBL· GenBank· DDBJ
BBA21111.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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