A0A223YSH5 · A0A223YSH5_9POLY
- ProteinLarge T antigen
- Genelarge T antigen
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids645 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Cofactor
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 155-269 | T-ag OBD | ||||
Sequence: PSELSSFLSNAVYSNKTVSAFLIYTTKEKGELLYEKIDKFKPDFKSRHAYEEAALLFIMTPGKHRVSAIKNFCLTHCTVSFLLCKAVTKPIECYRVLKQEPFAVVEESKQGLYDY |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell nucleus | |
Molecular Function | ATP binding | |
Molecular Function | DNA replication origin binding | |
Molecular Function | hydrolase activity | |
Molecular Function | metal ion binding | |
Biological Process | DNA replication | |
Biological Process | symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint | |
Biological Process | symbiont-mediated suppression of host innate immune response | |
Biological Process | symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity | |
Biological Process | symbiont-mediated suppression of host type I interferon-mediated signaling pathway | |
Biological Process | virus-mediated perturbation of host defense response |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLarge T antigen
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageViruses > Monodnaviria > Shotokuvirae > Cossaviricota > Papovaviricetes > Sepolyvirales > Polyomaviridae
Accessions
- Primary accessionA0A223YSH5
Proteomes
Subcellular Location
PTM/Processing
Keywords
- PTM
Expression
Keywords
- Developmental stage
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 12-81 | J | ||||
Sequence: ELMELLNVPAHCYGNMSMLKINYRKMSKIYHPDKGGDGTKMQRMNVLWQKLCDNICSARQESGYQHPPYG | ||||||
Region | 105-151 | Disordered | ||||
Sequence: LSSSDEDGPASSSTGQSNGHDSRQPGSSQSSFATPPKPKKPKTSHVP | ||||||
Compositional bias | 109-141 | Polar residues | ||||
Sequence: DEDGPASSSTGQSNGHDSRQPGSSQSSFATPPK | ||||||
Domain | 155-269 | T-ag OBD | ||||
Sequence: PSELSSFLSNAVYSNKTVSAFLIYTTKEKGELLYEKIDKFKPDFKSRHAYEEAALLFIMTPGKHRVSAIKNFCLTHCTVSFLLCKAVTKPIECYRVLKQEPFAVVEESKQGLYDY | ||||||
Domain | 277-369 | T-ag D1-type | ||||
Sequence: APTVDWNKLAEFAVDNRLDDPLIIMAFYLDFATDPDNCPKCNGLKMKMHYKFHAPHHKNAVLFKECKTQKTVCQQAADVVTAKTRLKLLESTR | ||||||
Domain | 409-569 | SF3 helicase | ||||
Sequence: DVEEKLYKILQLLVENVPKKRNVLFRGPINSGKTTFAAAILDLVGGKTLNINCPAEKLGFELGCAIDQFAVIFEDVKGQIAMNKSLHPGQGVCNLDNLRDYLDGSVRVNLEKKHVNKKSQIFPPSIVTMNEYVLPQTLLTRFSYILNFMPKDYLKKSLEAS |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length645
- Mass (Da)73,724
- Last updated2017-10-25 v1
- ChecksumCEDBBD7E872DB63A
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 109-141 | Polar residues | ||||
Sequence: DEDGPASSSTGQSNGHDSRQPGSSQSSFATPPK |