A0A223PLS5 · A0A223PLS5_9HEPC
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2986 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Cofactor
Protein has several cofactor binding sites:
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Hepacivirus
Accessions
- Primary accessionA0A223PLS5
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Endoplasmic reticulum membrane ; Single-pass type I membrane protein
Host endoplasmic reticulum membrane ; Multi-pass membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Single-pass type I membrane protein
Membrane ; Multi-pass membrane protein
Membrane ; Peripheral membrane protein
Membrane ; Single-pass type I membrane protein
Virion membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 718-740 | Helical | ||||
Sequence: YVILLFLLLADARICSCLWMMLL | ||||||
Transmembrane | 752-777 | Helical | ||||
Sequence: VLLNAASLAGTHGRVSFLVFFCFAWY | ||||||
Transmembrane | 783-803 | Helical | ||||
Sequence: VPGMAYAFYGIWPLFLLLLAL | ||||||
Transmembrane | 815-832 | Helical | ||||
Sequence: AASCGGVVLVGLMALTLS | ||||||
Transmembrane | 873-901 | Helical | ||||
Sequence: VILLMCVVHPALVFDITKLLLAVFGPLWI | ||||||
Transmembrane | 1660-1688 | Helical | ||||
Sequence: WVLVGGVLAALAAYCLSTGCVVIVGRVVL | ||||||
Transmembrane | 1816-1840 | Helical | ||||
Sequence: VAAQLAAPGAATAFVGAGLAGAAIG | ||||||
Transmembrane | 1847-1870 | Helical | ||||
Sequence: VLVDILAGYGAGVAGALVAFKIMI | ||||||
Transmembrane | 1882-1902 | Helical | ||||
Sequence: LLPAILSPGALVVGVVCAAIL |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-77 | Disordered | ||||
Sequence: MSTNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARRPEGRTWA | ||||||
Compositional bias | 47-69 | Basic and acidic residues | ||||
Sequence: RATRKTSERSQPRGRRQPIPKAR | ||||||
Domain | 899-1026 | Peptidase C18 | ||||
Sequence: LWILQTSLLKVPYFVRAQGLLRACALARKMAGGHYVQMAIIKMGALTGTYVYNHLTPLRDWAHSGLRDLAVAVEPVVFSPMETKLITWGADTAACGDIINGLPVSARRGREILLGPADGMVSKGWRLL | ||||||
Domain | 1027-1208 | Peptidase S29 | ||||
Sequence: APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRSISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVESLETTMRSP | ||||||
Domain | 1217-1369 | Helicase ATP-binding | ||||
Sequence: PAVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGVDANIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLVVLATATPPGSVTVPHPNIEEVALST | ||||||
Domain | 1361-1538 | Helicase C-terminal | ||||
Sequence: NIEEVALSTTGEIPFYGKAIPLEVIKGGRHLIFCHSRKKCDELAAKLVALGINAVAYYRGLDVSVIPTSGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVAPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVR | ||||||
Region | 2189-2210 | Disordered | ||||
Sequence: RLARGSPPSVASSSASQLSAPS | ||||||
Compositional bias | 2195-2210 | Polar residues | ||||
Sequence: PPSVASSSASQLSAPS | ||||||
Compositional bias | 2312-2329 | Pro residues | ||||
Sequence: HGCPLPPPRPPPVPPPRK | ||||||
Region | 2312-2333 | Disordered | ||||
Sequence: HGCPLPPPRPPPVPPPRKKRTV | ||||||
Compositional bias | 2351-2384 | Polar residues | ||||
Sequence: SFGSSSTSGITGDNTATSSEPAPSACSPDSDAES | ||||||
Region | 2351-2409 | Disordered | ||||
Sequence: SFGSSSTSGITGDNTATSSEPAPSACSPDSDAESYSSMPPLEGEPGDPDLSDGSWSTVS | ||||||
Domain | 2634-2752 | RdRp catalytic | ||||
Sequence: PMGFSYDTRCFDSTVTESDIRTEEAIYQCCDLDPQARVAIKSLTERLYVGGPLTNSRGENCGYRRCRASGVLTTSCGNTLTCYIKAQAACRAAGLRDCTMLVCGDDLVVICESQGVQED |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length2,986
- Mass (Da)324,384
- Last updated2017-10-25 v1
- Checksum45929F261CD95246
Features
Showing features for compositional bias, non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 47-69 | Basic and acidic residues | ||||
Sequence: RATRKTSERSQPRGRRQPIPKAR | ||||||
Compositional bias | 2195-2210 | Polar residues | ||||
Sequence: PPSVASSSASQLSAPS | ||||||
Compositional bias | 2312-2329 | Pro residues | ||||
Sequence: HGCPLPPPRPPPVPPPRK | ||||||
Compositional bias | 2351-2384 | Polar residues | ||||
Sequence: SFGSSSTSGITGDNTATSSEPAPSACSPDSDAES | ||||||
Non-terminal residue | 2986 | |||||
Sequence: R |