A0A221W529 · A0A221W529_9PSEU
- ProteinErythronolide synthase, modules 3 and 4
- GeneeryA1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3385 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.
Catalytic activity
- (2E)-butenoyl-[ACP] + H+ + NADPH = butanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- (2E)-decenoyl-[ACP] + H+ + NADPH = decanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- (2E)-dodecenoyl-[ACP] + H+ + NADPH = dodecanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- (2E)-hexadecenoyl-[ACP] + H+ + NADPH = hexadecanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- (2E)-hexenoyl-[ACP] + H+ + NADPH = hexanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- (2E)-octadecenoyl-[ACP] + H+ + NADPH = NADP+ + octadecanoyl-[ACP]This reaction proceeds in the forward direction.
- (2E)-octenoyl-[ACP] + H+ + NADPH = NADP+ + octanoyl-[ACP]This reaction proceeds in the forward direction.
- (2E)-tetradecenoyl-[ACP] + H+ + NADPH = NADP+ + tetradecanoyl-[ACP]This reaction proceeds in the forward direction.
- (3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2OThis reaction proceeds in the forward direction.
- (3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2OThis reaction proceeds in the forward direction.
- (3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2OThis reaction proceeds in the forward direction.
- (3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2OThis reaction proceeds in the forward direction.
- (3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2OThis reaction proceeds in the forward direction.
- (3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2OThis reaction proceeds in the forward direction.
- (3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2OThis reaction proceeds in the forward direction.
- (3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2OThis reaction proceeds in the forward direction.
- 3-oxobutanoyl-[ACP] + H+ + NADPH = (3R)-hydroxybutanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- 3-oxodecanoyl-[ACP] + H+ + NADPH = (3R)-hydroxydecanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- 3-oxododecanoyl-[ACP] + H+ + NADPH = (3R)-hydroxydodecanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- 3-oxohexadecanoyl-[ACP] + H+ + NADPH = (3R)-hydroxyhexadecanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- 3-oxohexanoyl-[ACP] + H+ + NADPH = (3R)-hydroxyhexanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- 3-oxooctadecanoyl-[ACP] + H+ + NADPH = (3R)-hydroxyoctadecanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- 3-oxooctanoyl-[ACP] + H+ + NADPH = (3R)-hydroxyoctanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- 3-oxotetradecanoyl-[ACP] + H+ + NADPH = (3R)-hydroxytetradecanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- H+ + hexadecanoyl-[ACP] + malonyl-[ACP] = 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]This reaction proceeds in the forward direction.
- H+ + hexanoyl-[ACP] + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]This reaction proceeds in the forward direction.
- H+ + malonyl-[ACP] + octanoyl-[ACP] = 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]This reaction proceeds in the forward direction.
- H+ + malonyl-[ACP] + tetradecanoyl-[ACP] = 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]This reaction proceeds in the forward direction.
- acetyl-[ACP] + H+ + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]This reaction proceeds in the forward direction.
- butanoyl-[ACP] + H+ + malonyl-[ACP] = 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]This reaction proceeds in the forward direction.
- decanoyl-[ACP] + H+ + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]This reaction proceeds in the forward direction.
- dodecanoyl-[ACP] + H+ + malonyl-[ACP] = 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]This reaction proceeds in the forward direction.
Pathway
Antibiotic biosynthesis.
Lipid metabolism.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 270 | Proton acceptor; for dehydratase activity | ||||
Sequence: H | ||||||
Active site | 435 | Proton donor; for dehydratase activity | ||||
Sequence: D |
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Pseudonocardiales > Pseudonocardiaceae > Actinoalloteichus
Accessions
- Primary accessionA0A221W529
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 238-359 | N-terminal hotdog fold | ||||
Sequence: HPLLGARVSVAGTDGLVLTGRISTRTHPWLADHVVHGTTIVPGTALVELAVHAGDHVGAPHLAELTLHTPLTLTRHDTQVQIVVGAPAENGERPLHVYSRPDDDASWTTHAGGVLLAEAYRP | ||||||
Domain | 238-513 | PKS/mFAS DH | ||||
Sequence: HPLLGARVSVAGTDGLVLTGRISTRTHPWLADHVVHGTTIVPGTALVELAVHAGDHVGAPHLAELTLHTPLTLTRHDTQVQIVVGAPAENGERPLHVYSRPDDDASWTTHAGGVLLAEAYRPAAADLTAWPPADAAALPFDGAALYSRLAAGGLAYGPAFRGLRAVWRRGDDVYAEVELPESERDRAAAFGLHPALLDAALHAVSFADLGAGDDRGLVPFAFSGVSLHATGADTLRVRLSPRGPDSLALTVADGTGAPVAAVESLVLRPMVADRLG | ||||||
Region | 374-513 | C-terminal hotdog fold | ||||
Sequence: ALPFDGAALYSRLAAGGLAYGPAFRGLRAVWRRGDDVYAEVELPESERDRAAAFGLHPALLDAALHAVSFADLGAGDDRGLVPFAFSGVSLHATGADTLRVRLSPRGPDSLALTVADGTGAPVAAVESLVLRPMVADRLG | ||||||
Region | 682-703 | Disordered | ||||
Sequence: PVVPRLGRLPNPGEPGGPLRPP | ||||||
Domain | 1298-1376 | Carrier | ||||
Sequence: ERRRTLLDLVRAQVAGVLGHPSPESVDPDRAFTDLGFDSLTAVELRNLLASATGLRLPATLTFDYPTPSALVAQLDADL | ||||||
Domain | 1395-1821 | Ketosynthase family 3 (KS3) | ||||
Sequence: AEPIAIVAMSCRFPGGVASPEDLWRLVAEGTDAIGDFPTDRGWDLAGMADSGQQRAGVSYVHEGGFVDGVGDFDPRFFGISPREALAMDPQQRLLLEASWEVLERAGVVPASLRGTPTGVFIGAASSGYGTGLAEMSEDLTGHLLTGNAGSVSSGRIAYVLGLEGPSMTVDTACSSSLVALHLASRSLAAGECSLALVGGVAVLATAGMFLEFSRQRGLAPDGRCKAFAEGADGTGWSEGVGVLLVERLSDARRLGHPVLAVVRGSAVNSDGASNGLTAPNGPSQQRVIRGALADAGLAASEVDAVEAHGTGTVLGDPIEAQALLATYGRDRPAGRPLWLGSLKSNIGHAQAAAGVAGVIKMVEAMRHGVLPKTLHVDAPTSQVDWEAGDIRLLTEATPWDGGDRPRRAGVSSFGISGTNAHVLLEE | ||||||
Region | 2285-2409 | N-terminal hotdog fold | ||||
Sequence: HPLLGAAADLADGGRTILTGTLSTARQPWLRWHSVAGTVLFPGAGFLELALHAADHVGCRRVDELVLAAPLTLPDDGVVQIQVVIADAEADGRRAVSVHSRAVGAADPDWTRHATGLLSPAAGPA | ||||||
Domain | 2285-2545 | PKS/mFAS DH | ||||
Sequence: HPLLGAAADLADGGRTILTGTLSTARQPWLRWHSVAGTVLFPGAGFLELALHAADHVGCRRVDELVLAAPLTLPDDGVVQIQVVIADAEADGRRAVSVHSRAVGAADPDWTRHATGLLSPAAGPAESLRAWPPEGTVPIELGAEENGVLAAWRADEEIFADVALPADLHDEAARFTLHPVLLTAALDAINLLGLDGALADGWMPFTWAGVSASAAGATAARVRLTRTAADTVALTLADGAGAPLATAESLVLRPPPAAPDA | ||||||
Region | 2420-2545 | C-terminal hotdog fold | ||||
Sequence: TVPIELGAEENGVLAAWRADEEIFADVALPADLHDEAARFTLHPVLLTAALDAINLLGLDGALADGWMPFTWAGVSASAAGATAARVRLTRTAADTVALTLADGAGAPLATAESLVLRPPPAAPDA | ||||||
Domain | 3020-3095 | Carrier | ||||
Sequence: DSLTDLVRTTAATILGFTDGESLAADEDLLAAGFDSLTAMELRNRLGTATGLRMAASVVFDHRTPAALARVLAEEL |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,385
- Mass (Da)352,036
- Last updated2017-10-25 v1
- ChecksumF2C01091D94C2220
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP022521 EMBL· GenBank· DDBJ | ASO20647.1 EMBL· GenBank· DDBJ | Genomic DNA |