A0A221I037 · A0A221I037_9EUTH

Function

function

Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncardiolipin binding
Molecular Functionlong-chain fatty acid binding
Molecular Functionoxidative phosphorylation uncoupler activity
Biological Processadaptive thermogenesis
Biological Processcellular response to fatty acid
Biological Processcellular response to hormone stimulus
Biological Processcellular response to reactive oxygen species
Biological Processmitochondrial transmembrane transport
Biological Processregulation of reactive oxygen species biosynthetic process
Biological Processresponse to cold
Biological Processresponse to nutrient levels

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Mitochondrial brown fat uncoupling protein 1
  • Short names
    UCP 1

Gene names

    • Name
      UCP1

Organism names

Accessions

  • Primary accession
    A0A221I037

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Keywords

PTM/Processing

Post-translational modification

May undergo ubiquitin-mediated proteasomal degradation.

Keywords

Interaction

Subunit

Most probably functions as a monomer. Binds one purine nucleotide per monomer. However, has also been suggested to function as a homodimer or a homotetramer. Tightly associates with cardiolipin in the mitochondrion inner membrane; may stabilize and regulate its activity.

Family & Domains

Features

Showing features for repeat.

TypeIDPosition(s)Description
Repeat11-102Solcar
Repeat111-201Solcar
Repeat210-295Solcar

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    307
  • Mass (Da)
    33,077
  • Last updated
    2017-10-25 v1
  • Checksum
    35997BA52953753D
MVGPTASDAPPTLAVKIFSAGAAACVADVITFPLDTAKVRLQIQGECQASSXVRYKGVLGTITTLAKTEGPMKLYSGLPAGLQRQISFASLRIGLYDTVQEFFTTGKETRASLGSKISAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGPKPRYTGTYNAYRIIATTEGLMGLWKGTTPNLTRNVIINCTELVTYDLMKEALVKNKLLADDVPCHFVSALIAGFCTTVLSSPVDVVKTRFVNSPPGQYASVPNCAMTMVTKEGPSAFFKGFVPSFLRLGSWNVIMFVCFEQLKRELMKSRQTMDCAT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY886645
EMBL· GenBank· DDBJ
ASM46962.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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