A0A220VX04 · A0A220VX04_9GOBI

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Gobiaria > Gobiiformes > Gobioidei > Gobiidae > Gobiinae > Buenia

Accessions

  • Primary accession
    A0A220VX04

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane22-52Helical
Transmembrane73-97Helical
Transmembrane117-140Helical
Transmembrane152-172Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-174Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    174
  • Mass (Da)
    18,420
  • Last updated
    2017-10-25 v1
  • Checksum
    76E6F43811B2B37D
ALSLLIRAELSQPGALLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLIPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGISSILGAINFITTIVNMKPPAISQYQTPLFVWAVLITAVLLLLSLPVLAAG

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue174

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY400549
EMBL· GenBank· DDBJ
ASK84805.1
EMBL· GenBank· DDBJ
Genomic DNA
KY400550
EMBL· GenBank· DDBJ
ASK84806.1
EMBL· GenBank· DDBJ
Genomic DNA
KY400551
EMBL· GenBank· DDBJ
ASK84807.1
EMBL· GenBank· DDBJ
Genomic DNA
KY400552
EMBL· GenBank· DDBJ
ASK84808.1
EMBL· GenBank· DDBJ
Genomic DNA
KY400553
EMBL· GenBank· DDBJ
ASK84809.1
EMBL· GenBank· DDBJ
Genomic DNA
KY400557
EMBL· GenBank· DDBJ
ASK84813.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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