A0A219YQN2 · A0A219YQN2_9EUCA

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Malacostraca > Eumalacostraca > Eucarida > Decapoda > Pleocyemata > Caridea > Palaemonoidea > Palaemonidae > Macrobrachium

Accessions

  • Primary accession
    A0A219YQN2

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane32-51Helical
Transmembrane63-85Helical
Transmembrane97-119Helical
Transmembrane131-157Helical
Transmembrane169-186Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-187Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    187
  • Mass (Da)
    20,741
  • Last updated
    2017-10-25 v1
  • Checksum
    6EB06F47A70DABE3
PEVYILILPAFGMISHIVSQESGKKESFGTLGMVYAMMAIGVLGFVVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWLATLHGTQFTYSPSLIWALGFIFLFTMGGLTGVVLANSSIDIILHDTYYVVAHFHYVLSMGAVFGIFAGIAHWYPLFTGLSLHPKWLKIHFTTMFIGVNLTFFP

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue187

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY111030
EMBL· GenBank· DDBJ
AQU43195.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111031
EMBL· GenBank· DDBJ
AQU43196.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111032
EMBL· GenBank· DDBJ
AQU43197.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111033
EMBL· GenBank· DDBJ
AQU43198.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111034
EMBL· GenBank· DDBJ
AQU43199.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111035
EMBL· GenBank· DDBJ
AQU43200.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111036
EMBL· GenBank· DDBJ
AQU43201.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111037
EMBL· GenBank· DDBJ
AQU43202.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111038
EMBL· GenBank· DDBJ
AQU43203.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111039
EMBL· GenBank· DDBJ
AQU43204.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111040
EMBL· GenBank· DDBJ
AQU43205.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111041
EMBL· GenBank· DDBJ
AQU43206.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111042
EMBL· GenBank· DDBJ
AQU43207.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111043
EMBL· GenBank· DDBJ
AQU43208.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111044
EMBL· GenBank· DDBJ
AQU43209.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111045
EMBL· GenBank· DDBJ
AQU43210.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111046
EMBL· GenBank· DDBJ
AQU43211.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111047
EMBL· GenBank· DDBJ
AQU43212.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111048
EMBL· GenBank· DDBJ
AQU43213.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111049
EMBL· GenBank· DDBJ
AQU43214.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111050
EMBL· GenBank· DDBJ
AQU43215.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111051
EMBL· GenBank· DDBJ
AQU43216.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111052
EMBL· GenBank· DDBJ
AQU43217.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111053
EMBL· GenBank· DDBJ
AQU43218.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111054
EMBL· GenBank· DDBJ
AQU43219.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111055
EMBL· GenBank· DDBJ
AQU43220.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111056
EMBL· GenBank· DDBJ
AQU43221.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111057
EMBL· GenBank· DDBJ
AQU43222.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111058
EMBL· GenBank· DDBJ
AQU43223.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111059
EMBL· GenBank· DDBJ
AQU43224.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111060
EMBL· GenBank· DDBJ
AQU43225.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111061
EMBL· GenBank· DDBJ
AQU43226.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111062
EMBL· GenBank· DDBJ
AQU43227.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111063
EMBL· GenBank· DDBJ
AQU43228.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111064
EMBL· GenBank· DDBJ
AQU43229.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111065
EMBL· GenBank· DDBJ
AQU43230.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111066
EMBL· GenBank· DDBJ
AQU43231.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111067
EMBL· GenBank· DDBJ
AQU43232.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111068
EMBL· GenBank· DDBJ
AQU43233.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111069
EMBL· GenBank· DDBJ
AQU43234.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111070
EMBL· GenBank· DDBJ
AQU43235.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111071
EMBL· GenBank· DDBJ
AQU43236.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111072
EMBL· GenBank· DDBJ
AQU43237.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111073
EMBL· GenBank· DDBJ
AQU43238.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111074
EMBL· GenBank· DDBJ
AQU43239.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111075
EMBL· GenBank· DDBJ
AQU43240.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111076
EMBL· GenBank· DDBJ
AQU43241.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111077
EMBL· GenBank· DDBJ
AQU43242.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111078
EMBL· GenBank· DDBJ
AQU43243.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111079
EMBL· GenBank· DDBJ
AQU43244.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111080
EMBL· GenBank· DDBJ
AQU43245.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111081
EMBL· GenBank· DDBJ
AQU43246.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111082
EMBL· GenBank· DDBJ
AQU43247.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111083
EMBL· GenBank· DDBJ
AQU43248.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111084
EMBL· GenBank· DDBJ
AQU43249.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111085
EMBL· GenBank· DDBJ
AQU43250.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111086
EMBL· GenBank· DDBJ
AQU43251.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111087
EMBL· GenBank· DDBJ
AQU43252.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111088
EMBL· GenBank· DDBJ
AQU43253.1
EMBL· GenBank· DDBJ
Genomic DNA
KY111089
EMBL· GenBank· DDBJ
AQU43254.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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