A0A219YQN2 · A0A219YQN2_9EUCA
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids187 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)This reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Malacostraca > Eumalacostraca > Eucarida > Decapoda > Pleocyemata > Caridea > Palaemonoidea > Palaemonidae > Macrobrachium
Accessions
- Primary accessionA0A219YQN2
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 32-51 | Helical | ||||
Sequence: GMVYAMMAIGVLGFVVWAHH | ||||||
Transmembrane | 63-85 | Helical | ||||
Sequence: AYFTSATMIIAVPTGIKIFSWLA | ||||||
Transmembrane | 97-119 | Helical | ||||
Sequence: SLIWALGFIFLFTMGGLTGVVLA | ||||||
Transmembrane | 131-157 | Helical | ||||
Sequence: YYVVAHFHYVLSMGAVFGIFAGIAHWY | ||||||
Transmembrane | 169-186 | Helical | ||||
Sequence: WLKIHFTTMFIGVNLTFF |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-187 | Cytochrome oxidase subunit I profile | ||||
Sequence: PEVYILILPAFGMISHIVSQESGKKESFGTLGMVYAMMAIGVLGFVVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWLATLHGTQFTYSPSLIWALGFIFLFTMGGLTGVVLANSSIDIILHDTYYVVAHFHYVLSMGAVFGIFAGIAHWYPLFTGLSLHPKWLKIHFTTMFIGVNLTFFP |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length187
- Mass (Da)20,741
- Last updated2017-10-25 v1
- Checksum6EB06F47A70DABE3
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: P | ||||||
Non-terminal residue | 187 | |||||
Sequence: P |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KY111030 EMBL· GenBank· DDBJ | AQU43195.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111031 EMBL· GenBank· DDBJ | AQU43196.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111032 EMBL· GenBank· DDBJ | AQU43197.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111033 EMBL· GenBank· DDBJ | AQU43198.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111034 EMBL· GenBank· DDBJ | AQU43199.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111035 EMBL· GenBank· DDBJ | AQU43200.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111036 EMBL· GenBank· DDBJ | AQU43201.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111037 EMBL· GenBank· DDBJ | AQU43202.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111038 EMBL· GenBank· DDBJ | AQU43203.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111039 EMBL· GenBank· DDBJ | AQU43204.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111040 EMBL· GenBank· DDBJ | AQU43205.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111041 EMBL· GenBank· DDBJ | AQU43206.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111042 EMBL· GenBank· DDBJ | AQU43207.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111043 EMBL· GenBank· DDBJ | AQU43208.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111044 EMBL· GenBank· DDBJ | AQU43209.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111045 EMBL· GenBank· DDBJ | AQU43210.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111046 EMBL· GenBank· DDBJ | AQU43211.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111047 EMBL· GenBank· DDBJ | AQU43212.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111048 EMBL· GenBank· DDBJ | AQU43213.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111049 EMBL· GenBank· DDBJ | AQU43214.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111050 EMBL· GenBank· DDBJ | AQU43215.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111051 EMBL· GenBank· DDBJ | AQU43216.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111052 EMBL· GenBank· DDBJ | AQU43217.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111053 EMBL· GenBank· DDBJ | AQU43218.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111054 EMBL· GenBank· DDBJ | AQU43219.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111055 EMBL· GenBank· DDBJ | AQU43220.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111056 EMBL· GenBank· DDBJ | AQU43221.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111057 EMBL· GenBank· DDBJ | AQU43222.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111058 EMBL· GenBank· DDBJ | AQU43223.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111059 EMBL· GenBank· DDBJ | AQU43224.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111060 EMBL· GenBank· DDBJ | AQU43225.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111061 EMBL· GenBank· DDBJ | AQU43226.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111062 EMBL· GenBank· DDBJ | AQU43227.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111063 EMBL· GenBank· DDBJ | AQU43228.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111064 EMBL· GenBank· DDBJ | AQU43229.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111065 EMBL· GenBank· DDBJ | AQU43230.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111066 EMBL· GenBank· DDBJ | AQU43231.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111067 EMBL· GenBank· DDBJ | AQU43232.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111068 EMBL· GenBank· DDBJ | AQU43233.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111069 EMBL· GenBank· DDBJ | AQU43234.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111070 EMBL· GenBank· DDBJ | AQU43235.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111071 EMBL· GenBank· DDBJ | AQU43236.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111072 EMBL· GenBank· DDBJ | AQU43237.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111073 EMBL· GenBank· DDBJ | AQU43238.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111074 EMBL· GenBank· DDBJ | AQU43239.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111075 EMBL· GenBank· DDBJ | AQU43240.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111076 EMBL· GenBank· DDBJ | AQU43241.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111077 EMBL· GenBank· DDBJ | AQU43242.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111078 EMBL· GenBank· DDBJ | AQU43243.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111079 EMBL· GenBank· DDBJ | AQU43244.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111080 EMBL· GenBank· DDBJ | AQU43245.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111081 EMBL· GenBank· DDBJ | AQU43246.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111082 EMBL· GenBank· DDBJ | AQU43247.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111083 EMBL· GenBank· DDBJ | AQU43248.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111084 EMBL· GenBank· DDBJ | AQU43249.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111085 EMBL· GenBank· DDBJ | AQU43250.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111086 EMBL· GenBank· DDBJ | AQU43251.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111087 EMBL· GenBank· DDBJ | AQU43252.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111088 EMBL· GenBank· DDBJ | AQU43253.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY111089 EMBL· GenBank· DDBJ | AQU43254.1 EMBL· GenBank· DDBJ | Genomic DNA |