A0A219UWA0 · A0A219UWA0_9PERO
- ProteinRhodopsin
- GeneRho
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids252 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling.
Features
Showing features for site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 72 | Plays an important role in the conformation switch to the active conformation | |||
Binding site | 160 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 238 | Zn2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | photoreceptor outer segment | |
Molecular Function | G protein-coupled photoreceptor activity | |
Molecular Function | metal ion binding | |
Biological Process | cellular response to light stimulus | |
Biological Process | phototransduction | |
Biological Process | visual perception |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameRhodopsin
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Perciformes > Percoidei > Percidae > Etheostomatinae > Etheostoma
Accessions
- Primary accessionA0A219UWA0
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 6-22 | Helical | |||
Transmembrane | 34-54 | Helical | |||
Transmembrane | 74-92 | Helical | |||
Transmembrane | 113-132 | Helical | |||
Transmembrane | 162-182 | Helical | |||
Transmembrane | 213-235 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Disulfide bond | 69↔146 | ||||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 13-252 | G-protein coupled receptors family 1 profile | |||
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
Keywords
- Domain
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusFragment
- Length252
- Mass (Da)28,523
- Last updated2017-10-25 v1
- ChecksumA86757C1CDEC689E
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 252 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KX145932 EMBL· GenBank· DDBJ | ANY44312.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX146043 EMBL· GenBank· DDBJ | ANY44423.1 EMBL· GenBank· DDBJ | Genomic DNA |