A0A219UW99 · A0A219UW99_FUNHE

Function

function

Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Features

Showing features for site, binding site.

124720406080100120140160180200220240
Type
IDPosition(s)Description
Site68Plays an important role in the conformation switch to the active conformation
Binding site156Zn2+ (UniProtKB | ChEBI)
Binding site234Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentphotoreceptor outer segment
Molecular FunctionG protein-coupled photoreceptor activity
Molecular Functionmetal ion binding
Biological Processcellular response to light stimulus
Biological Processphototransduction
Biological Processvisual perception

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Rhodopsin

Gene names

    • Name
      Rho

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Cyprinodontiformes > Fundulidae > Fundulus

Accessions

  • Primary accession
    A0A219UW99

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane30-50Helical
Transmembrane70-88Helical
Transmembrane109-128Helical
Transmembrane158-178Helical
Transmembrane209-231Helical

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond65↔142

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-223G-protein coupled receptors family 1 profile

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

Keywords

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Fragment
  • Length
    247
  • Mass (Da)
    27,820
  • Last updated
    2017-10-25 v1
  • MD5 Checksum
    1001E752A9FD36B8296775F4A92CD951
FLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNLEGFFATLGGEIGLWSLVVLAIERWLVVCKPISNFRFTENHAIMGLAFTWVMAAACAVPPLVGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVVYMFVCHFIIPLVIVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVIIMVIGFLVCWCPYAGVAWYIFTNQGTEFGPLFMTVPA

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue247

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KX146037
EMBL· GenBank· DDBJ
ANY44417.1
EMBL· GenBank· DDBJ
Genomic DNA
KX146047
EMBL· GenBank· DDBJ
ANY44427.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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