A0A219PSF9 · A0A219PSF9_ASTOC
- Proteinaromatase
- Genecyp19a
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids136 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Catalytic activity
- 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone = 17beta-estradiol + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
Cofactor
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | heme binding | |
Molecular Function | iron ion binding | |
Molecular Function | monooxygenase activity | |
Molecular Function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namearomatase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Cichlomorphae > Cichliformes > Cichlidae > New World cichlids > Astronotinae > Astronotini > Astronotus
Accessions
- Primary accessionA0A219PSF9
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Peripheral membrane protein
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-24 | |||||
Sequence: APDTLSISLFFMLLLLKQNPHVEL | ||||||
Chain | PRO_5012035923 | 25-136 | aromatase | |||
Sequence: QLLQEIDTLVGERQLQNQDLHKLQVLESFINECLRFHPVVDFTMRRALSDDIIEGYRVPKGTNIILNTGRMHRTEFFLKASEFNLENFEQNVPRRYFQPFGSGPRACIGKHI |
Structure
Sequence
- Sequence statusFragment
- Length136
- Mass (Da)15,854
- Last updated2017-10-25 v1
- Checksum4B2902B5DAE434B0
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: A | ||||||
Non-terminal residue | 136 | |||||
Sequence: I |