A0A219PSF9 · A0A219PSF9_ASTOC

Function

function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site131Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functionheme binding
Molecular Functioniron ion binding
Molecular Functionmonooxygenase activity
Molecular Functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    aromatase
  • EC number
  • Alternative names
    • Cytochrome P-450AROM
    • Estrogen synthase

Gene names

    • Name
      cyp19a

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Cichlomorphae > Cichliformes > Cichlidae > New World cichlids > Astronotinae > Astronotini > Astronotus

Accessions

  • Primary accession
    A0A219PSF9

Subcellular Location

Membrane
; Peripheral membrane protein

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_501203592325-136aromatase

Family & Domains

Sequence similarities

Belongs to the cytochrome P450 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    136
  • Mass (Da)
    15,854
  • Last updated
    2017-10-25 v1
  • Checksum
    4B2902B5DAE434B0
APDTLSISLFFMLLLLKQNPHVELQLLQEIDTLVGERQLQNQDLHKLQVLESFINECLRFHPVVDFTMRRALSDDIIEGYRVPKGTNIILNTGRMHRTEFFLKASEFNLENFEQNVPRRYFQPFGSGPRACIGKHI

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue136

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KT337400
EMBL· GenBank· DDBJ
AMD33518.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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