A0A218V7U6 · A0A218V7U6_9PASE
- ProteinCholesteryl ester transfer protein
- GeneCETP
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids481 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination.
Catalytic activity
- 1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol(out)
- cholesteryl (9Z,12Z)-octadecadienoate(in) = cholesteryl (9Z,12Z)-octadecadienoate(out)
- cholesteryl (9Z-octadecenoate)(in) = cholesteryl (9Z-octadecenoate)(out)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | high-density lipoprotein particle | |
Molecular Function | cholesterol binding | |
Molecular Function | cholesterol transfer activity | |
Molecular Function | phosphatidylcholine binding | |
Molecular Function | phospholipid transporter activity | |
Molecular Function | triglyceride binding | |
Biological Process | cholesterol homeostasis | |
Biological Process | cholesterol metabolic process | |
Biological Process | high-density lipoprotein particle remodeling | |
Biological Process | low-density lipoprotein particle remodeling | |
Biological Process | phosphatidylcholine metabolic process | |
Biological Process | phospholipid homeostasis | |
Biological Process | reverse cholesterol transport | |
Biological Process | triglyceride homeostasis | |
Biological Process | triglyceride metabolic process | |
Biological Process | triglyceride transport | |
Biological Process | very-low-density lipoprotein particle remodeling |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameCholesteryl ester transfer protein
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Lonchura
Accessions
- Primary accessionA0A218V7U6
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-24 | ||||
Chain | PRO_5012239644 | 25-481 | Cholesteryl ester transfer protein | ||
Disulfide bond | 169↔210 | ||||
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 40-267 | Lipid-binding serum glycoprotein N-terminal | |||
Domain | 281-481 | Lipid-binding serum glycoprotein C-terminal | |||
Sequence similarities
Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length481
- Mass (Da)53,667
- Last updated2017-09-27 v1
- MD5 ChecksumE59AE76E437798F645326C9B549D8B2F
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 481 | ||||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MUZQ01000037 EMBL· GenBank· DDBJ | OWK61662.1 EMBL· GenBank· DDBJ | Genomic DNA |