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A0A218V7U6 · A0A218V7U6_9PASE

Function

function

Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

GO annotations

AspectTerm
Cellular Componenthigh-density lipoprotein particle
Molecular Functioncholesterol binding
Molecular Functioncholesterol transfer activity
Molecular Functionphosphatidylcholine binding
Molecular Functionphospholipid transporter activity
Molecular Functiontriglyceride binding
Biological Processcholesterol homeostasis
Biological Processcholesterol metabolic process
Biological Processhigh-density lipoprotein particle remodeling
Biological Processlow-density lipoprotein particle remodeling
Biological Processphosphatidylcholine metabolic process
Biological Processphospholipid homeostasis
Biological Processreverse cholesterol transport
Biological Processtriglyceride homeostasis
Biological Processtriglyceride metabolic process
Biological Processtriglyceride transport
Biological Processvery-low-density lipoprotein particle remodeling

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cholesteryl ester transfer protein

Gene names

    • Name
      CETP
    • ORF names
      RLOC_00000330

Organism names

  • Taxonomic identifier
  • Strain
    • White83orange57
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Lonchura

Accessions

  • Primary accession
    A0A218V7U6

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-24
ChainPRO_501223964425-481Cholesteryl ester transfer protein
Disulfide bond169↔210

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain40-267Lipid-binding serum glycoprotein N-terminal
Domain281-481Lipid-binding serum glycoprotein C-terminal

Sequence similarities

Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    481
  • Mass (Da)
    53,667
  • Last updated
    2017-09-27 v1
  • MD5 Checksum
    E59AE76E437798F645326C9B549D8B2F
MCWAGRIMLGAFSIFLGLVHAAAACEFGPFPYRGTGIVCRMTEPAALLLNKEVAQVIQAAFRNAKFPNVTGERSLRLLGRVAYTLSHIQVNDLSIERSEVELKEDSAIHISIRNVTALFKGSLTYGYAGAWFLQLFHSVDFEIESSIDLQLNINLMCQKDKVAPDASDCYLTFHKLTLHLQGDKEPGWLKQLFTDFISFTLKLVLKREVCKEINAVAQMLTNYVIDLAANFVRDKDIIVDISLTSDPVIKARYIESHHKGIVLYKNNSSVLSDSVFSPSLLTESRMLYFWLSEHSLSSLAAAAFLDGQLLLHLRGEKLQELFEMEDTEVQRKAVQRIFQGTSYNDSVAKVWSLTQPQISFQPEGTVVRSSVAVEVSILLAGEEPLVALYMEKEITATIQATYAEKKLILQPVDSRVEIKVFKCTADPSGEDPSIQSFLQNMILVAGIPEVTSSIGSALTSLMNSKRLDLFDIINPEIITRQ

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue481

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MUZQ01000037
EMBL· GenBank· DDBJ
OWK61662.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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