A0A218UU38 · A0A218UU38_9PASE

Function

function

Protein hedgehog N-product

The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

Protein hedgehog

The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Features

Showing features for binding site, site.

142250100150200250300350400
Type
IDPosition(s)Description
Binding site92Ca2+ 1 (UniProtKB | ChEBI)
Binding site93Ca2+ 1 (UniProtKB | ChEBI)
Binding site93Ca2+ 2 (UniProtKB | ChEBI)
Binding site98Ca2+ 1 (UniProtKB | ChEBI)
Binding site128Ca2+ 1 (UniProtKB | ChEBI)
Binding site129Ca2+ 1 (UniProtKB | ChEBI)
Binding site129Ca2+ 2 (UniProtKB | ChEBI)
Binding site132Ca2+ 2 (UniProtKB | ChEBI)
Binding site134Ca2+ 2 (UniProtKB | ChEBI)
Binding site143Zn2+ (UniProtKB | ChEBI)
Binding site150Zn2+ (UniProtKB | ChEBI)
Binding site185Zn2+ (UniProtKB | ChEBI)
Site200-201Cleavage; by autolysis
Site246Involved in cholesterol transfer
Site270Involved in auto-cleavage
Site273Essential for auto-cleavage

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentextracellular space
Cellular ComponentGolgi membrane
Cellular Componentplasma membrane
Molecular Functioncalcium ion binding
Molecular Functionpatched binding
Molecular Functionpeptidase activity
Molecular Functiontransferase activity
Biological Processanimal organ development
Biological Processcell development
Biological Processcell fate specification
Biological Processcell-cell signaling
Biological Processneuron differentiation
Biological Processoligodendrocyte differentiation
Biological Processprotein autoprocessing
Biological Processregulation of gene expression
Biological Processsmoothened signaling pathway
Biological Processtissue development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Hedgehog protein

Gene names

    • Name
      SHH
    • ORF names
      RLOC_00003971

Organism names

  • Taxonomic identifier
  • Strain
    • White83orange57
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Lonchura

Accessions

  • Primary accession
    A0A218UU38

Proteomes

Subcellular Location

Endoplasmic reticulum membrane

Sonic hedgehog protein

Endoplasmic reticulum membrane
Golgi apparatus membrane

Protein hedgehog N-product

Cell membrane
; Lipid-anchor

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-26
ChainPRO_501210358327-422Hedgehog protein

Keywords

Interaction

Subunit

Multimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain199-307Hint
Domain309-354Hint

Sequence similarities

Belongs to the hedgehog family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    422
  • Mass (Da)
    46,338
  • Last updated
    2017-09-27 v1
  • Checksum
    93F02A7D33DBD494
MDEMLLLTRILLVGFICALLVSSGLTCGPGRGIGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSATVHLEKGGTKLVKDLRPGDRVLVADTEGRLLYSDFLTFLDREDGSQKLFYVIETRQPRARLLLTAAHLLFVAPQQNQSQAGGGRALFASRVRPGQRVFVLGEGGRLLPAAVHRVSLREEASGAYAPLTAQGTILIDRVLASCYAVIEEHSWAHWAFAPFRLLQAVLAALGPSAAGSPVGEPAAPGIHWYSRLLYRIGSWVLDGDSLHPLGMMVSSS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MUZQ01000145
EMBL· GenBank· DDBJ
OWK56872.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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