A0A218UTZ0 · A0A218UTZ0_9PASE

Function

function

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site251-259ATP (UniProtKB | ChEBI)
Binding site278ATP (UniProtKB | ChEBI)
Active site380Proton acceptor

GO annotations

AspectTerm
Cellular Componentmembrane raft
Cellular Componentplasma membrane
Cellular Componentreceptor complex
Molecular Functionactivin receptor activity, type I
Molecular Functionactivin receptor activity, type II
Molecular FunctionATP binding
Molecular FunctionBMP receptor activity
Molecular Functionmetal ion binding
Molecular Functiontransforming growth factor beta receptor activity, type I
Molecular Functiontransforming growth factor beta receptor activity, type II
Molecular Functiontransforming growth factor beta receptor activity, type III
Biological Processanatomical structure morphogenesis
Biological Processapoptotic process
Biological Processcell differentiation
Biological Processheart development
Biological Processtissue development

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    TGF-beta receptor type-2
  • EC number
  • Short names
    TGFR-2
  • Alternative names
    • TGF-beta type II receptor
    • Transforming growth factor-beta receptor type II

Gene names

    • Name
      TGFBR2_1
    • ORF names
      RLOC_00009398

Organism names

  • Taxonomic identifier
  • Strain
    • White83orange57
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Lonchura

Accessions

  • Primary accession
    A0A218UTZ0

Proteomes

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Membrane raft
Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane167-189Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-32
ChainPRO_501239749233-568TGF-beta receptor type-2
Disulfide bond52↔85
Disulfide bond55↔72
Disulfide bond62↔68
Disulfide bond78↔102
Disulfide bond122↔137
Disulfide bond139↔144

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain245-548Protein kinase

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    568
  • Mass (Da)
    64,685
  • Last updated
    2017-09-27 v1
  • MD5 Checksum
    26D07EAE8BB08607FD06E9A8838B161D
MTPRLPSSLRRLLLRLSLWALMGSSVPALLRAEFTSPVERNKEGGLKMPNLCKFCDIKVTTCSNQHQCKSNCNITSICEKSSEVCVAIWRQNDENVTLETICHDPEETLYGHFLDDYKSEQCLMREKKDDGGLMFMCSCTGEECNDMLIFTSDDPHKPEEKDEISKVTIISLVPLLVISVAVIVIFYAYRTHKKRKLSKTWEKNVKPKKHKDCSDVCAIMLDDDRSDISSTCANNINHNTELLPIELDVVVGKGRFAEVYKAKLKQNTSEQYETVAVKIFSYEEYASWKTEKDIFSDVNLKHENILQFLTAEERKTDLGKQYWLITAFHAKGNLQEYLTRHIISWEDLWKLGGSLARGIAHLHSDHTPCGRPKTPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPSLSVDDLANSGQVGTARYMAPEVLESRMNLENMESFKQTDVYSMALVLWEMTSRCNAVGEVKEYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSSWLNHQGIQMVCETLIECWDHDPEARLTAQCVAERFSELKHHDRLSGRSCSEEKIPEDGSVTTAK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MUZQ01000138
EMBL· GenBank· DDBJ
OWK57011.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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