A0A218PXL4 · A0A218PXL4_9CYAN

  • Protein
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • Gene
    gpsA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site13-18NAD+ (UniProtKB | ChEBI)
Binding site17NADPH (UniProtKB | ChEBI)
Binding site37NADPH (UniProtKB | ChEBI)
Binding site38NADPH (UniProtKB | ChEBI)
Binding site85NADPH (UniProtKB | ChEBI)
Binding site85sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site85substrate
Binding site113sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site117NADPH (UniProtKB | ChEBI)
Active site168Proton acceptor
Binding site168sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site221sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site231sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site232NAD+ (UniProtKB | ChEBI)
Binding site232NADPH (UniProtKB | ChEBI)
Binding site232sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site232-233substrate
Binding site233sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site258NADPH (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglycerol-3-phosphate dehydrogenase (NADP+) activity
Molecular Functionglycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Molecular FunctionNAD binding
Biological Processcarbohydrate metabolic process
Biological Processglycerol-3-phosphate biosynthetic process
Biological Processglycerol-3-phosphate catabolic process
Biological Processglycerophospholipid metabolic process
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • EC number
  • Alternative names
    • NAD(P)(+)-dependent glycerol-3-phosphate dehydrogenase
    • NAD(P)H-dependent dihydroxyacetone-phosphate reductase

Gene names

    • Name
      gpsA
    • ORF names
      NIES3585_03810

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NIES-3585
  • Taxonomic lineage
    Bacteria > Cyanobacteriota > Cyanophyceae > Nostocales > Aphanizomenonaceae > Nodularia

Accessions

  • Primary accession
    A0A218PXL4

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_501339291223-311Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-38Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Domain40-137Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Domain157-297Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    311
  • Mass (Da)
    32,843
  • Last updated
    2017-09-27 v1
  • Checksum
    9A1C8940460F1B34
MIAVQKTTIAILGAGAWGLALADLASANGHQVRVWSRRGTANLAAVVQDAQIILSAISMKGVSDVVCQVKSCPLSPKTIFVTATKGLDPKTTCTPSQIWQTAFPHHPVVVLSGPNLSKEIQQSLPAATVAASNDTAAAELVQLVFSSPHFRVYTNPDPLGVELGGTLKNIMAIASGVCDGLHLGTNAKAALVTRGLTEIVRIGQSWGAKTETFYGLSGLGDLLATCNSPLSRNYQVGYQMAGGKTLTEILANLPGTAEGVNTCQVLVQRAKQHSIAIPITEQVYRLLEGEITPRQALSELMLRDTKAEYNC

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BDUB01000001
EMBL· GenBank· DDBJ
GAX34380.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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