A0A218PAR2 · A0A218PAR2_9EURY

  • Protein
    Mevalonate kinase
  • Gene
    mvk
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site109-119ATP (UniProtKB | ChEBI)
Active site160Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Molecular Functionmevalonate kinase activity
Biological Processisopentenyl diphosphate biosynthetic process, mevalonate pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mevalonate kinase
  • EC number
  • Short names
    MK
    ; MVK

Gene names

    • Name
      mvk
    • ORF names
      A3L12_00925

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • P6
  • Taxonomic lineage
    Archaea > Euryarchaeota > Thermococci > Thermococcales > Thermococcaceae > Thermococcus

Accessions

  • Primary accession
    A0A218PAR2

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain102-168GHMP kinase N-terminal
Domain242-310GHMP kinase C-terminal

Sequence similarities

Belongs to the GHMP kinase family. Mevalonate kinase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    333
  • Mass (Da)
    35,502
  • Last updated
    2017-09-27 v1
  • Checksum
    5AC73D05F8C1BA6B
MRVLASAPAKVILFGEHSVVYGKPAIAAAIDLRTYVRAGFNENGAIKIEARDIKVPGLTVSFSENEIYFESDYGKAAEVLSYVRQAIELVREEADKRKGVTVSITSQIPVGAGLGSSAAVAIATIGAVSRLFGLELTREEIGKLGHKVELLVQGASSGIDPTVSALGGFIHYENRKFERLPFMELPIVVGYTGSSGSTKELVAMVRRTYEEMPEVVEPLLVAMGRIVEKARGLLLSEVEERARFEELGRLMNINHGLLDALGVSTKKLSELVYAARTAGAVGAKITGAGGGGCMYALAPENQSEVATAIKIAGGVPMITKISREGLRIEEVKP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP015104
EMBL· GenBank· DDBJ
ASJ09960.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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