A0A218P1F2 · A0A218P1F2_THECE

Function

function

Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site44Mg2+ (UniProtKB | ChEBI)
Binding site44-453-methyl-2-oxobutanoate (UniProtKB | ChEBI)
Binding site833-methyl-2-oxobutanoate (UniProtKB | ChEBI)
Binding site83Mg2+ (UniProtKB | ChEBI)
Binding site1123-methyl-2-oxobutanoate (UniProtKB | ChEBI)
Binding site114Mg2+ (UniProtKB | ChEBI)
Active site181Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Molecular Functionmetal ion binding
Molecular Functionmethyltransferase activity
Biological Processcoenzyme A biosynthetic process
Biological Processmethylation
Biological Processpantothenate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-methyl-2-oxobutanoate hydroxymethyltransferase
  • EC number
  • Alternative names
    • Ketopantoate hydroxymethyltransferase
      (KPHMT
      )

Gene names

    • Name
      panB
    • ORF names
      A3L02_03765

Organism names

Accessions

  • Primary accession
    A0A218P1F2

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodecamer; pentamer of dimers.

Family & Domains

Sequence similarities

Belongs to the PanB family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    285
  • Mass (Da)
    31,952
  • Last updated
    2017-09-27 v1
  • Checksum
    8E118F4D7677CC26
MREITPRKIIEMKGKERIAMVTAYDYPSALIADRAGMDIIFVGDSLGMVVYGEENTLNVTMEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGVRNAVRLIRAGADAVKIEGGYDHRKLVRKLVRMGIPVMGHTGLTPQRYLRLGGYRLMGETEEEIEEILRDARALEKAGAFAVVLEFTLADVSRLVTEEVSIPTIGIGAGPYVDGQVLVWHDLLGIYENVPPFVKKYADIGGMIRLALENYREDVKGGKFPAKEHYWEFLDKDDFRRKAGRALEKLEEDG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP014854
EMBL· GenBank· DDBJ
ASI98741.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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