Physiological and pathological roles of LRRK2 in the nuclear envelope integrity.
- AnnotationData indicate that LRRK2 plays an essential role in maintaining nuclear envelope integrity. Disruption of this function by disease mutations suggests a novel phosphorylation-independent loss-of-function mechanism that may synergize with other neurotoxic effects caused by LRRK2 mutations.
- CategoriesInteraction, Subcellular Location
- SourceGeneRif: 120892