A0A212D3R3 · A0A212D3R3_CEREH
- ProteinAlkaline phosphatase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids524 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- ADP + H2O = AMP + phosphate + H+This reaction proceeds in the forward direction.
- AMP + H2O = adenosine + phosphateThis reaction proceeds in the forward direction.
- ATP + H2O = ADP + phosphate + H+This reaction proceeds in the forward direction.
- phosphoethanolamine + H2O = ethanolamine + phosphateThis reaction proceeds in the forward direction.
- pyridoxal 5'-phosphate + H2O = pyridoxal + phosphateThis reaction proceeds in the forward direction.
- diphosphate + H2O = 2 phosphate + H+This reaction proceeds in the forward direction.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Mg2+ ion.
Note: Binds 2 Zn2+ ions.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 60 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 60 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 110 | Phosphoserine intermediate | ||||
Sequence: S | ||||||
Binding site | 171 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 173 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 332 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 337 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 341 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 378 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 379 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 454 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial intermembrane space | |
Cellular Component | mitochondrial membrane | |
Cellular Component | plasma membrane | |
Cellular Component | side of membrane | |
Molecular Function | ADP phosphatase activity | |
Molecular Function | alkaline phosphatase activity | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | inorganic diphosphate phosphatase activity | |
Molecular Function | metal ion binding | |
Molecular Function | phosphoamidase activity | |
Molecular Function | phosphoethanolamine phosphatase activity | |
Molecular Function | pyridoxal phosphatase activity | |
Biological Process | dephosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAlkaline phosphatase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Cervidae > Cervinae > Cervus
Accessions
- Primary accessionA0A212D3R3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Lipid-anchor, GPI-anchor
Extracellular vesicle membrane ; Lipid-anchor, GPI-anchor
Mitochondrion membrane ; Lipid-anchor, GPI-anchor
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-17 | |||||
Sequence: MISPFLVLAIGTCLTNC | ||||||
Chain | PRO_5012329474 | 18-524 | Alkaline phosphatase | |||
Sequence: LVPEKEKDPKYWREQAQQTLKNALRLQTLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNVKDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLNLIDIWKSFKPKHKHSHYVWNRTDLLALDPHTVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVEMAIKILNKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACIGANRDHCASASSSSSPAPGPLLLLLALLPLGSLF |
Keywords
- PTM
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length524
- Mass (Da)57,301
- Last updated2017-09-27 v1
- Checksum2A86C8CC5976840D
Keywords
- Technical term