A0A210PZS6 · A0A210PZS6_MIZYE

Function

function

GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site58GTP (UniProtKB | ChEBI)
Site80Important for substrate specificity
Binding site91-93GTP (UniProtKB | ChEBI)
Binding site147GTP (UniProtKB | ChEBI)
Site148Important for substrate specificity
Binding site244Mg2+ (UniProtKB | ChEBI)
Binding site258Mg2+ (UniProtKB | ChEBI)
Binding site309substrate; ligand shared with subunit alpha
Binding site366-368substrate; ligand shared with subunit alpha

GO annotations

AspectTerm
Cellular Componentmitochondrion
Cellular Componentsuccinate-CoA ligase complex
Molecular FunctionATP binding
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Molecular Functionsuccinate-CoA ligase (ADP-forming) activity
Molecular Functionsuccinate-CoA ligase (GDP-forming) activity
Biological Processsuccinyl-CoA metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
  • EC number
  • Alternative names
    • GTP-specific succinyl-CoA synthetase subunit beta
      (G-SCS
      ; GTPSCS
      )
    • Succinyl-CoA synthetase beta-G chain
      (SCS-betaG
      )

Gene names

    • ORF names
      KP79_PYT11018

Organism names

Accessions

  • Primary accession
    A0A210PZS6

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain40-246ATP-grasp fold succinyl-CoA synthetase-type
Domain307-425ATP-citrate synthase/succinyl-CoA ligase C-terminal

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    431
  • Mass (Da)
    46,772
  • Last updated
    2017-09-27 v1
  • Checksum
    F9FB30625C84EAC0
MAAPMQILRSSMRLSSYRCLCKSRWNRKAAAVTIPSRNLNLQEYQSKKLMEDGGVSVQKFVMASSPDEAKTAAERLTVDEYVIKAQILAGGRGKGTFSNGFKGGVHLTKDPSKVEGIVENMLGNKLTTKQTSADGVKVNQVMVAEALDIAKETYFAIVMDRGYNGPVMVGSKHGGVDIEETAEKDPDSIIKEAVDIVTGITEEQALRMAEKLDFTGEHLQQAATQITRLYNLFVKVDATQLEINPFGETPDGRVVCFDAKLNFDDNAEFRQKEIFEMEDTSETDPREIEASRLKLNYIGLEGSIGCLVNGAGLAMATMDIIKLHGGEPANFLDVGGGVSEQQVYDAFQLLTADSHVKGILVNVFGGIVNCATVATGILKACQRIDLKLPLVVRLEGQNVEAGRKILEESNLPIKAAFGFEEAAKLAVASVK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NEDP02005326
EMBL· GenBank· DDBJ
OWF41982.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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