A0A200PM20 · A0A200PM20_MACCD

Function

function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Allosterically activated by AMP.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.

Features

Showing features for binding site, site, active site.

Type
IDPosition(s)Description
Binding site117ATP (UniProtKB | ChEBI)
Binding site180-181ATP (UniProtKB | ChEBI)
Binding site205-208ATP (UniProtKB | ChEBI)
Binding site206Mg2+ (UniProtKB | ChEBI); catalytic
Site207Important for substrate specificity; cannot use PPi as phosphoryl donor
Binding site234-236substrate
Active site236Proton acceptor
Binding site279-281substrate
Binding site335substrate
Binding site393-396substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function6-phosphofructokinase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processfructose 6-phosphate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent 6-phosphofructokinase
  • EC number
  • Short names
    ATP-PFK
    ; Phosphofructokinase
  • Alternative names
    • Phosphohexokinase

Gene names

    • Name
      PFK
    • ORF names
      BVC80_8769g21

Organism names

Accessions

  • Primary accession
    A0A200PM20

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain109-417Phosphofructokinase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    472
  • Mass (Da)
    52,463
  • Last updated
    2017-09-27 v1
  • Checksum
    4CAE53ECDCFE1E12
MADTDITKTTFETTKPEKTHLQNHFFSPINLQTVPHVTDYLPNLQSFTNPLDHNPFYYPSDGFYVSTSDVILRQIVYDLASSFPVSDPHFAYHRAGPRKEIFFDPSHVRAAIVTCGGLCPGLNTVIRELVIGLWELYGVREISGVTAGYWGFYTMEPKPLDPKLVHDWHKRGGTLLETSRGGFDLQKIVDAIEDHGFNQVYIIGGDGTMRGAVKIFDEICKRKLNISVTGIPKTVDNDIGIIDRSFGFQTAVEVAQQAINAGHVEAESAVNGIGLVKLMGRSTGHIALHATLSSRDVDCCLIPENDFYLEGKGGLFQFLEHRLKQNGHAVVVVAEGAGQDLITRTDAQKEEKDESGNPVFLDVGVWLKSELKQWWERDHKGELFTVKYIDPTYMIRAVPANATDNSYCTLLAHSAIHGVMAGYTGFFSGPINGNYAYIPLAEVAQAKNVVNTKDHKWSWVRSVTNQPDFVKS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MVGT01004524
EMBL· GenBank· DDBJ
OUZ99256.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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