These results together with the reported data on p202 HINb lead to an interaction model for full-length p202 and dsDNA which provides a conceivable mechanism for the negative regulation of Aim2 inflammasome activation by p202.
Authors hypothesize that while p202 was evolutionarily selected to limit AIM2-mediated inflammation in some mouse strains the same mechanism contributes to increased interferon production and lupus susceptibility.
expression of Aim2 protein is required to maintain the expression of the Fcgr2b gene and also predict epistatic interactions between the Ifi200 genes and the Fcgr2b gene within the Nba2 interval
Findings delineate a new role of the IFN-gamma signaling pathway in regulating T cell proliferation and apoptosis through upregulating survivin and ifi202 expression.
Results suggest that Ifi202 expression in the kidney and immune organs significantly increased with disease progression in autoimmune glomerulonephritis.
study showed p202 is an inhibitor of DNA-induced caspase activation; conversely AIM2 was required for caspase activation by cytoplasmic dsDNA; work indicates HIN-200 proteins can act as pattern recognition receptors mediating response to cytoplasmic dsDNA
Ifi202 is an important NF-kappaB activator in dendritic cells and is involved in IL-12 production which may account for a T(h)1-prone phenotype of BWF1 mice
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