A0A1Z1NEK3 · A0A1Z1NEK3_9GAMA

Function

function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site202substrate
Binding site217-218substrate
Site218Important for hydrogen atom transfer
Binding site248substrate
Active site417Proton acceptor
Binding site417-421substrate
Active site419Cysteine radical intermediate
Active site421Proton acceptor
Site433Important for hydrogen atom transfer
Binding site613-617substrate
Site744Important for electron transfer
Site745Important for electron transfer
Site774Interacts with thioredoxin/glutaredoxin

GO annotations

AspectTerm
Cellular Componentribonucleoside-diphosphate reductase complex
Molecular FunctionATP binding
Molecular Functionribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Biological Processdeoxyribonucleotide biosynthetic process
Biological ProcessDNA replication
Biological Processviral process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonucleoside-diphosphate reductase large subunit
  • EC number
  • Short names
    R1
  • Alternative names
    • Ribonucleotide reductase large subunit

Gene names

    • Name
      ORF61
    • Synonyms
      RIR1

Organism names

Accessions

  • Primary accession
    A0A1Z1NEK3

Proteomes

PTM/Processing

Keywords

Expression

Keywords

Interaction

Subunit

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain591-613Ribonucleotide reductase large subunit

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    797
  • Mass (Da)
    89,441
  • Last updated
    2017-09-27 v1
  • Checksum
    9EAB1DACA95E4595
MAGYGSSHSTSESLAAALINHLKVSAGFDKEANALAGRLEHWIYDKHSTQSVGEYLDVFKDVLDSSVVKFLADNEENLDVYCSLFKNSPAYERLITVGVLSAKRLFDTYVLRACDVRASQGPPFAGAAAGGSLGPGAVYESVTHFFMRIAAFCACQCMRHEFLRKTIAEIQKKDWGERVEGPMELFDYFFKPLSRQLVCCATPVMRSAGVKDGNLASCFIYAPDLFSEERTAAALFHELSALLAVKSGVGIDITRFSHEKNVHNCLKLMNAQVEYYNDHNPRPVSVAAYIELWHFQIQEFLASKLPETQDRCASIFQGLCIPGLFFETYLRDPGESWYLFDPAMAGNLSSLHGEEFNREYARLVAAGAYSSKVSAKSLMFAIINTIIKTGSPYIILKEACNRHYWRETQGGAIAAANLCAEVIQHPGDVVSTCNLANICLPKCLVKEEFKSRRGRHFHDQYDEHGEYFSMEVLHKAVQVATFVVNAAIVGGRCPTEATFVGQMERSMGIGVHGLADVFARLRYEYIEDGAAKLDVRIFENMYFKAVETSHRIVLWGGGTPFKGWEESKLSKGVFHWEGWKDVKLSIPAEQWNDLRRSIVGTGVFNSQYVALMPTTGSSQLTGYNESYYPFYANISSKVSNKEEVMRPNAVFLEQLCATDLKTVRFYGGDVWKFPDKLRAKYRYFLSAFDYSPREQLIRARERAPFIDHSQSHSFFLNEASVVSARYIKDLLVLGYQLGLKTIMYYCRVKKETNLGALECLEGPESNGVIKTPRCSRAELAGYNKETRDAVNECESCQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY965444
EMBL· GenBank· DDBJ
ARW78123.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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