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A0A1Z1NCV9 · A0A1Z1NCV9_LACJH

  • Protein
    Fluoride-specific ion channel FluC
  • Gene
    crcB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

Catalytic activity

Activity regulation

Na+ is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

Features

Showing features for binding site.

1119102030405060708090100110
TypeIDPosition(s)Description
Binding site70Na+ (UniProtKB | ChEBI); structural
Binding site73Na+ (UniProtKB | ChEBI); structural

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionfluoride channel activity
Molecular Functionmetal ion binding
Biological Processcellular detoxification of fluoride

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Fluoride-specific ion channel FluC

Gene names

    • Name
      crcB
    • Synonyms
      fluC
    • ORF names
      A3Q24_03830
      , GTO82_06415

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • UMNLJ114
    • 3DG
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Lactobacillales > Lactobacillaceae > Lactobacillus

Accessions

  • Primary accession
    A0A1Z1NCV9

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane34-52Helical
Transmembrane59-79Helical
Transmembrane91-113Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    119
  • Mass (Da)
    13,221
  • Last updated
    2017-10-25 v1
  • MD5 Checksum
    C388338F0D8A9E00621F007F658698F8
MITVLTAGFGAIWGAILRYGITNYGKKHWSEKFPYATLLINLTGAFLLGFIFSRKFSPFIYALIGTGVLGGYTTFSTLNVELLSHWRDRNYSVFTLYALLSYGGGLILVFLGYKVGTLI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NIBD01000020
EMBL· GenBank· DDBJ
PAB55711.1
EMBL· GenBank· DDBJ
Genomic DNA
CP047409
EMBL· GenBank· DDBJ
QLL68487.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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