Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L.[...], Ponting C.P.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]StrainC57BL/6JCategorySequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCPLoS Biol. 7:E1000112-E1000112 (2009)Cited in99+99+
A tissue-specific atlas of mouse protein phosphorylation and expression.Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.View abstractCited forIDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]CategorySequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCCell 143:1174-1189 (2010)Cited in99+99+Mapped to6
Modernizing reference genome assemblies.Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N., Chen H.C., Agarwala R., McLaren W.M.[...], Hubbard T.Cited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]StrainC57BL/6JCategorySequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCPLoS Biol 9:e1001091-e1001091 (2011)Cited in99+
No title available.EnsemblCited forIDENTIFICATIONStrainC57BL/6JSourceUniProtKB unreviewed (TrEMBL)Submission Submitted to UniProtKB (AUG-2024)Cited in99+
ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice.Nakagawa O., Fujisawa K., Ishizaki T., Saito Y., Nakao K., Narumiya S.View abstractCategorySequencesSourceMGI: 107926PubMedEurope PMCFEBS Lett. 392:189-193 (1996)Cited in2Mapped to12
Conditional deficiency of Rho-associated kinases disrupts endothelial cell junctions and impairs respiratory function in adult mice.Akamine T., Terabayashi T., Sasaki T., Hayashi R., Abe I., Hirayama F., Nureki S.I., Ikawa M., Miyata H.[...], Ishizaki T.View abstractSourceMGI: 107926PubMedEurope PMCFEBS Open Bio 14:906-921 (2024)Mapped to21
Aberrant centrosome biogenesis disrupts nephron and collecting duct progenitor growth and fate resulting in fibrocystic kidney disease.Cheng T., Agwu C., Shim K., Wang B., Jain S., Mahjoub M.R.View abstractCategoryFunctionSourceMGI: 107926PubMedEurope PMCDevelopment 150:dev201976-dev201976 (2023)Mapped to99+
ROCK2-induced metabolic rewiring in diabetic podocytopathy.Matoba K., Takeda Y., Nagai Y., Sekiguchi K., Ukichi R., Takahashi H., Aizawa D., Ikegami M., Tachibana T.[...], Nishimura R.View abstractCategoriesFunction, Expression, Phenotypes & VariantsSourceMGI: 107926PubMedEurope PMCCommun Biol 5:341-341 (2022)Mapped to9
Conditional deletion of ROCK2 induces anxiety-like behaviors and alters dendritic spine density and morphology on CA1 pyramidal neurons.Weber A.J., Adamson A.B., Greathouse K.M., Andrade J.P., Freeman C.D., Seo J.V., Rae R.J., Walker C.K., Herskowitz J.H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107926PubMedEurope PMCMol Brain 14:169-169 (2021)Mapped to9
Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes.Scheiblich H., Dansokho C., Mercan D., Schmidt S.V., Bousset L., Wischhof L., Eikens F., Odainic A., Spitzer J.[...], Heneka M.T.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107926PubMedEurope PMCCell 184:5089-5106.e21 (2021)Mapped to30
miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer's disease.Zheng K., Hu F., Zhou Y., Zhang J., Zheng J., Lai C., Xiong W., Cui K., Hu Y.Z.[...], Zhu L.Q.View abstractCategoryFunctionSourceMGI: 107926PubMedEurope PMCNat Commun 12:1903-1903 (2021)Mapped to19
LncRNA THRIL aggravates sepsis-induced acute lung injury by regulating miR-424/ROCK2 axis.Chen H., Hu X., Li R., Liu B., Zheng X., Fang Z., Chen L., Chen W., Min L., Hu S.View abstractCategoryFunctionSourceMGI: 107926PubMedEurope PMCMol Immunol 126:111-119 (2020)Mapped to9
Serine-threonine kinase ROCK2 regulates germinal center B cell positioning and cholesterol biosynthesis.Ricker E., Chinenov Y., Pannellini T., Flores-Castro D., Ye C., Gupta S., Manni M., Liao J.K., Pernis A.B.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107926PubMedEurope PMCJ Clin Invest 130:3654-3670 (2020)Mapped to12
ROCK2 inhibition enhances the thermogenic program in white and brown fat tissue in mice.Wei L., Surma M., Yang Y., Tersey S., Shi J.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107926PubMedEurope PMCFASEB J 34:474-493 (2020)Mapped to14
Epidermal ROCK2 induces AKT1/GSK3beta/beta-catenin, NFkappaB and dermal tenascin C; but enhanced differentiation and p53/p21 inhibit papilloma.Masre S.F., Rath N., Olson M.F., Greenhalgh D.A.View abstractCategoryFunctionSourceMGI: 107926PubMedEurope PMCCarcinogenesis 41:1409-1420 (2020)Mapped to9
A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease.McKerracher L., Shenkar R., Abbinanti M., Cao Y., Peiper A., Liao J.K., Lightle R., Moore T., Hobson N.[...], Awad I.A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107926PubMedEurope PMCTransl Stroke Res 11:365-376 (2020)Mapped to9
Gamma Interferon Alters Junctional Integrity via Rho Kinase, Resulting in Blood-Brain Barrier Leakage in Experimental Viral Encephalitis.Bonney S., Seitz S., Ryan C.A., Jones K.L., Clarke P., Tyler K.L., Siegenthaler J.A.View abstractCategoryFunctionSourceMGI: 107926PubMedEurope PMCmBio 10:e01675-19 (2019)Mapped to20
Fasudil or genetic depletion of ROCK1 or ROCK2 induces anxiety-like behaviors.Greathouse K.M., Henderson B.W., Gentry E.G., Herskowitz J.H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107926PubMedEurope PMCBehav Brain Res 373:112083-112083 (2019)Mapped to14
Disruption of both ROCK1 and ROCK2 genes in cardiomyocytes promotes autophagy and reduces cardiac fibrosis during aging.Shi J., Surma M., Yang Y., Wei L.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107926PubMedEurope PMCFASEB J 33:7348-7362 (2019)Mapped to16
Comparative Study of ROCK1 and ROCK2 in Hippocampal Spine Formation and Synaptic Function.Yan J., Pan Y., Zheng X., Zhu C., Zhang Y., Shi G., Yao L., Chen Y., Xu N.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107926PubMedEurope PMCNeurosci Bull 35:649-660 (2019)Mapped to14
Distinct and complementary functions of rho kinase isoforms ROCK1 and ROCK2 in prefrontal cortex structural plasticity.Greathouse K.M., Boros B.D., Deslauriers J.F., Henderson B.W., Curtis K.A., Gentry E.G., Herskowitz J.H.View abstractCategoryFunctionSourceMGI: 107926PubMedEurope PMCBrain Struct Funct 223:4227-4241 (2018)Mapped to14
Different roles of myocardial ROCK1 and ROCK2 in cardiac dysfunction and postcapillary pulmonary hypertension in mice.Sunamura S., Satoh K., Kurosawa R., Ohtsuki T., Kikuchi N., Elias-Al-Mamun M., Shimizu T., Ikeda S., Suzuki K.[...], Shimokawa H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107926PubMedEurope PMCProc Natl Acad Sci U S A 115:E7129-E7138 (2018)Mapped to14
Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice.Hiroi Y., Noma K., Kim H.H., Sladojevic N., Tabit C.E., Li Y., Soydan G., Salomone S., Moskowitz M.A., Liao J.K.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107926PubMedEurope PMCCirc J 82:1195-1204 (2018)Mapped to26
The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis.Knipe R.S., Probst C.K., Lagares D., Franklin A., Spinney J.J., Brazee P.L., Grasberger P., Zhang L., Black K.E.[...], Tager A.M.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107926PubMedEurope PMCAm J Respir Cell Mol Biol 58:471-481 (2018)Mapped to14
ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs.Mrass P., Oruganti S.R., Fricke G.M., Tafoya J., Byrum J.R., Yang L., Hamilton S.L., Miller M.J., Moses M.E., Cannon J.L.View abstractCategoryFunctionSourceMGI: 107926PubMedEurope PMCNat Commun 8:1010-1010 (2017)Mapped to14