A0A1Y3QPY8 · A0A1Y3QPY8_9BACL

Function

function

Catalyzes the conversion of dihydroorotate to orotate with NAD+ as electron acceptor.
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (NAD+ route): step 1/1.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site71-75FMN (UniProtKB | ChEBI)
Binding site75substrate
Binding site95FMN (UniProtKB | ChEBI)
Binding site120-124substrate
Binding site149FMN (UniProtKB | ChEBI)
Binding site182FMN (UniProtKB | ChEBI)
Binding site182substrate
Active site185Nucleophile
Binding site187substrate
Binding site228FMN (UniProtKB | ChEBI)
Binding site256FMN (UniProtKB | ChEBI)
Binding site257-258substrate
Binding site278FMN (UniProtKB | ChEBI)
Binding site307FMN (UniProtKB | ChEBI)
Binding site328-329FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular Functiondihydroorotate dehydrogenase (NAD+) activity
Molecular Functiondihydroorotate dehydrogenase (quinone) activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotate dehydrogenase (quinone)
  • EC number
  • Alternative names
    • DHOdehase
      (DHOD
      ; DHODase
      )
    • Dihydroorotate oxidase

Gene names

    • Name
      pyrD
    • ORF names
      BAA02_09985

Organism names

Accessions

  • Primary accession
    A0A1Y3QPY8

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Membrane

Keywords

Interaction

Subunit

Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain54-350Dihydroorotate dehydrogenase catalytic

Sequence similarities

Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    371
  • Mass (Da)
    40,163
  • Last updated
    2017-08-30 v1
  • Checksum
    8DFCD6767DDC5F72
MPSFYETACKPLLFCLDPEKAHHLVVGGLGIFGRMPGAAELMSAAWGVPDLPELAVELFGFRFRHPVGLAAGMDKDAKAVRGFAAIGLAFLEVGTVTPLGQPGNEKPRLFRLPSDGALINRMGFNNEGAEAMASRLGRLGPRPVPVAVNIGKNKATPNEEAERDYRKCLRVLYPYGDLFVVNVSSPNTPDLRRLQHGDDLRKLLDAVRDEIRIQAERTGGPEKPVLVKISPDNDDTQLERIARTVMESGVAGVVCTNTTIERQGLTHRHAAETGGLSGRPLAARSTEVIRKMYALTEGRLPIIGVGGIFDAAGAYEKIRAGASLLEVYTALVYKGPGVVKEICRGLAELLRRDGFARLADAVGADHRQERR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LZRV01000042
EMBL· GenBank· DDBJ
OUN00547.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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