A0A1Y3QPY8 · A0A1Y3QPY8_9BACL
- ProteinDihydroorotate dehydrogenase (quinone)
- GenepyrD
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids371 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the conversion of dihydroorotate to orotate with NAD+ as electron acceptor.
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Catalytic activity
- (S)-dihydroorotate + NAD+ = orotate + NADH + H+
Cofactor
Note: Binds 1 FMN per subunit.
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (NAD+ route): step 1/1.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 71-75 | FMN (UniProtKB | ChEBI) | |||
Binding site | 75 | substrate | |||
Binding site | 95 | FMN (UniProtKB | ChEBI) | |||
Binding site | 120-124 | substrate | |||
Binding site | 149 | FMN (UniProtKB | ChEBI) | |||
Binding site | 182 | FMN (UniProtKB | ChEBI) | |||
Binding site | 182 | substrate | |||
Active site | 185 | Nucleophile | |||
Binding site | 187 | substrate | |||
Binding site | 228 | FMN (UniProtKB | ChEBI) | |||
Binding site | 256 | FMN (UniProtKB | ChEBI) | |||
Binding site | 257-258 | substrate | |||
Binding site | 278 | FMN (UniProtKB | ChEBI) | |||
Binding site | 307 | FMN (UniProtKB | ChEBI) | |||
Binding site | 328-329 | FMN (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | dihydroorotate dehydrogenase (NAD+) activity | |
Molecular Function | dihydroorotate dehydrogenase (quinone) activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | 'de novo' UMP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydroorotate dehydrogenase (quinone)
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Paenibacillaceae
Accessions
- Primary accessionA0A1Y3QPY8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
Interaction
Subunit
Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
Monomer.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length371
- Mass (Da)40,163
- Last updated2017-08-30 v1
- Checksum8DFCD6767DDC5F72
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LZRV01000042 EMBL· GenBank· DDBJ | OUN00547.1 EMBL· GenBank· DDBJ | Genomic DNA |