A0A1Y3PTF6 · A0A1Y3PTF6_9BACI

  • Protein
    Multifunctional fusion protein
  • Gene
    purM
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 2/2.
Purine metabolism; IMP biosynthesis via de novo pathway; N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide from N1-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site448-450N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI)
Binding site501(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Binding site526-529(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Binding site543(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Active site545Proton donor
Site581Raises pKa of active site His

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionphosphoribosylamine-glycine ligase activity
Molecular Functionphosphoribosylformylglycinamidine cyclo-ligase activity
Molecular Functionphosphoribosylglycinamide formyltransferase activity
Biological Process'de novo' IMP biosynthetic process
Biological Processadenine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Phosphoribosylformylglycinamidine cyclo-ligase
  • EC number
  • Alternative names
    • AIR synthase
    • AIRS
    • Phosphoribosyl-aminoimidazole synthetase
  • Recommended name
    Phosphoribosylglycinamide formyltransferase
  • EC number
  • Alternative names
    • 5'-phosphoribosylglycinamide transformylase
    • GAR transformylase
      (GART
      )

Gene names

    • Name
      purM
    • Synonyms
      purN
    • ORF names
      BAA01_02255

Organism names

Accessions

  • Primary accession
    A0A1Y3PTF6

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain66-171PurM-like N-terminal
Domain183-351PurM-like C-terminal
Region354-439Disordered
Domain439-618Formyl transferase N-terminal

Sequence similarities

Belongs to the AIR synthase family.
Belongs to the GART family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    630
  • Mass (Da)
    67,250
  • Last updated
    2017-08-30 v1
  • Checksum
    532FD97FD68E47D5
MAEGSTREGLTRDAYREAGVDIEAGNRAVERMKRHVQRTFRPEVLSGLGGFGALFRLDTARYREPVLVSGSDGVGTKLMLAQALDRHGTIGIDAVAMCVNDVVVQGAEPLFFLDYLALGKVIPEKVEQIVAGVAEGCRQAGCALIGGETAEMPGMYAPEEYDIAGFAVGVAEADKLVDGRRIRAGDRLIGLASSGLHSNGFSLVRHLLLEKAGFDLRQPLDELNGRELGEVLLTPTRIYVKTVLRLLERHDIKGMAHITGGGFLENIPRILPPGLGAEIWLGAWPVPPVFRLLQQVGQLSQGECYRTFNMGIGLVLAVAPEEAETVLDAARRLGEEAFLIGQVVPGKGVRLVEGNGNRASDGAGNRATEGSADGGAQGIREGNREGNAEGFRESAGVSTSENRESGATEESGETRESGAAGESGGTGDPGAGSPSPLPRLAVFASGNGSNFQALADACGSGEIPARIALLVTDRPDCTAVERAKRLEIPVLALRPKDFPDKASYERQILNRLQEERVDWVVLAGYMRLVGPTLLSAYEGKMINLHPSLLPAFPGKDAIGQAWRHGVKVTGVTVHFVDEGMDTGPIFLQEPVPVEPGDTLESLEERIHRVEHRLLVEAVRRLVSRPAEANG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LZRT01000011
EMBL· GenBank· DDBJ
OUM90663.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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