A0A1Y2HET3 · A0A1Y2HET3_9FUNG

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      BCR44DRAFT_1515571

Organism names

  • Taxonomic identifier
  • Strain
    • PL171
  • Taxonomic lineage
    Eukaryota > Fungi > Fungi incertae sedis > Blastocladiomycota > Blastocladiomycetes > Blastocladiales > Catenariaceae > Catenaria

Accessions

  • Primary accession
    A0A1Y2HET3

Proteomes

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-30Helical
Transmembrane125-145Helical
Transmembrane165-188Helical
Transmembrane200-220Helical
Transmembrane226-244Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    272
  • Mass (Da)
    28,190
  • Last updated
    2017-08-30 v1
  • Checksum
    4D0CAF53E8C1F396
MDLEWTTGPALAALVGLVLCVVSVFAALALTRPRMLHASSPESSYYDIGASSSDRDDSGSYSSGTAARTSHDSSILARKSFSSGLLANRDSPTPYPIAAIAKALNASQASSAATQKSILQLGASFWIVCLLAILLYGSVMPFINITQTCLSHHPVIQSKWYPGDLQTAGALMSLPDLLCAILTPLFGLIADKLGGQPTRLLPLSGVLLAIAHSLLFFTSLPPAPSLVLLGIGTATFLATLWPTVSMLVPDALLGTAIGAVQVAVNAALAACR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MCFL01000049
EMBL· GenBank· DDBJ
ORZ32213.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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