A0A1Y1Y7K4 · A0A1Y1Y7K4_9FUNG

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      K493DRAFT_191634

Organism names

  • Taxonomic identifier
  • Strain
    • CBS 931.73
  • Taxonomic lineage
    Eukaryota > Fungi > Fungi incertae sedis > Zoopagomycota > Entomophthoromycotina > Basidiobolomycetes > Basidiobolales > Basidiobolaceae > Basidiobolus

Accessions

  • Primary accession
    A0A1Y1Y7K4

Proteomes

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane13-33Helical
Transmembrane40-59Helical
Transmembrane134-153Helical
Transmembrane192-213Helical
Transmembrane261-278Helical
Transmembrane284-302Helical
Transmembrane314-336Helical
Transmembrane342-366Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-367Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    367
  • Mass (Da)
    40,067
  • Last updated
    2017-08-30 v1
  • Checksum
    9C82E43E218E06A1
EIDVNDWQYKVNLLFSVTSLPNVIFPFISGILIDKIGSKFALILFTTTLCIGHALFAFGISVKTFWIMCLGRTLFGIGSGSAEIVQNKLTTDWFRGSLLAFALALNLTFDRWAAAGDAIVSPRLFHFFGNVPMVTWFGLGMCLVSAFCSFLLIRMDTPRARIRSGVNLESKGDTADGSQDIKINDILNLKPAFWLLCVLAVTLYGSVQPFLYISSDYLQSEKYPGRPETAGTVMSIPSLLSSFGTPLCGLMIDRVGHHSELMTFSALVVILVHGLLAFTSITPVLPYIMLGFGYSLFAAALWPSVPSLVHERQLGTGIGISVIAFNLSITGVPMVIARIRVWTGSFFAIQLFFMALAFCGLLAGLLL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue367

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MCFE01000217
EMBL· GenBank· DDBJ
ORX93958.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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