A0A1Y1NIZ7 · A0A1Y1NIZ7_PHOPY

Function

function

Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress.

Catalytic activity

  • 2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • 2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H+
    This reaction proceeds in the forward direction.
    EC:3.6.1.56 (UniProtKB | ENZYME | Rhea)
  • 8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • 8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • N6-methyl-ATP + H2O = N6-methyl-AMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • N6-methyl-dATP + H2O = N6-methyl-dAMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • O6-methyl-dGTP + H2O = O6-methyl-dGMP + diphosphate + H+
    This reaction proceeds in the forward direction.

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
Molecular Functionmetal ion binding
Biological ProcessDNA protection

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Oxidized purine nucleoside triphosphate hydrolase
  • EC number
  • Alternative names
    • 2-hydroxy-dATP diphosphatase
    • 7,8-dihydro-8-oxoguanine triphosphatase
    • 8-oxo-dGTPase
    • Methylated purine nucleoside triphosphate hydrolase
    • Nucleoside diphosphate-linked moiety X motif 1

Organism names

Accessions

  • Primary accession
    A0A1Y1NIZ7

Subcellular Location

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-127Nudix hydrolase

Sequence similarities

Belongs to the Nudix hydrolase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    163
  • Mass (Da)
    18,799
  • Last updated
    2017-08-30 v1
  • Checksum
    2070DC12B2459F43
MKQKIYTLVFVKKQNEVLLGLKVRGFGVGLWNGFGGKVEQGESIQEGAKRELKEESNLDVDKLKHVGIVTYKEDFCRAIVHVFTTHNTTSHLKASEEMNPVTWYNFSNIPYQKMWPDAKLWYPYMLRDEHFLAEITYVGNKITETLITPCNANEIQTVLKSLV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GEZM01006571
EMBL· GenBank· DDBJ
JAV95717.1
EMBL· GenBank· DDBJ
Transcribed RNA

Similar Proteins

Disclaimer

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