A0A1Y1LQE0 · A0A1Y1LQE0_PHOPY

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      PPYR_08391

Organism names

Accessions

  • Primary accession
    A0A1Y1LQE0

Proteomes

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane42-62Helical
Transmembrane82-102Helical
Transmembrane114-137Helical
Transmembrane210-232Helical
Transmembrane261-284Helical
Transmembrane304-321Helical
Transmembrane328-347Helical
Transmembrane353-374Helical
Transmembrane386-409Helical
Transmembrane415-438Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain44-443Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    524
  • Mass (Da)
    58,511
  • Last updated
    2017-08-30 v1
  • Checksum
    636CDDD4C4FB127C
MERRLEDNSQLCINASVSDSFEQDTSSCSYICCHPKGSGHRFIALFFMCWLGFGSYFCFDTPSSLINTFKEDLHLTNTEFSLLYSLYSWPTVVLCVVGGILVDSVFGIRLGANIYMLITLVGQVCFASGALFNVFWLMVLGRFIFGMGAEPLAVAQNNYAVLWFKGKELNMVFGVQLSFARLGSAANFWVMEPVYDWMKEYYTGYKCLGIVLFIATTTCLLSMICSIILGCIDKRAERILRRNENTPKEVIRFKNVKEFSLHFWLISIICVSYYIAIFVFISFGKEFFMKRFGLSSDAANKVNSMIYLISSVGSPVLGFAVDKIGKNLFWIILSIIATICGHYVLAFATWNPYIGMVVMGVAYSLLASSLWPLVSLIIPEHQLGTAYGICQSIQNLGLALGAIFAGKIVDDYGHIWLEVFFICSLFISLVASIIMLFFDTAANGPLNMTPAQRDRHQKSVLAAQALEREKLISAGVASSTSSSQDLLNSNSDFHIRNRYLSRIGAPLPANYDITMKGLAYRALR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GEZM01054161
EMBL· GenBank· DDBJ
JAV73815.1
EMBL· GenBank· DDBJ
Transcribed RNA
GEZM01054160
EMBL· GenBank· DDBJ
JAV73816.1
EMBL· GenBank· DDBJ
Transcribed RNA
GEZM01054159
EMBL· GenBank· DDBJ
JAV73817.1
EMBL· GenBank· DDBJ
Transcribed RNA
VVIM01000006
EMBL· GenBank· DDBJ
KAB0797397.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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