A0A1Y1JV98 · A0A1Y1JV98_PHOPY

Function

function

Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle.

Catalytic activity

  • 2-oxoadipate(in) + 2-oxoglutarate(out) = 2-oxoadipate(out) + 2-oxoglutarate(in)
  • 2-oxoheptanedioate(in) + 2-oxoglutarate(out) = 2-oxoheptanedioate(out) + 2-oxoglutarate(in)
  • L-2-aminoadipate(in) + 2-oxoglutarate(out) = L-2-aminoadipate(out) + 2-oxoglutarate(in)
  • citrate(in) + 2-oxoglutarate(out) = citrate(out) + 2-oxoglutarate(in)
  • glutarate(in) + 2-oxoglutarate(out) = glutarate(out) + 2-oxoglutarate(in)
  • heptanedioate(in) + 2-oxoglutarate(out) = heptanedioate(out) + 2-oxoglutarate(in)
  • hexanedioate(in) + 2-oxoglutarate(out) = hexanedioate(out) + 2-oxoglutarate(in)

GO annotations

AspectTerm
Cellular Componentmembrane

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Mitochondrial 2-oxodicarboxylate carrier
  • Alternative names
    • Solute carrier family 25 member 21

Organism names

Accessions

  • Primary accession
    A0A1Y1JV98

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Keywords

Family & Domains

Features

Showing features for repeat.

TypeIDPosition(s)Description
Repeat8-102Solcar

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    116
  • Mass (Da)
    13,075
  • Last updated
    2017-08-30 v1
  • Checksum
    2FDA22F243778913
MEIKKILKEAGIQIGAGGSAGFVEVCIMHPLDLIKTRLQIQSGKPTGKVSDPNRYSGIFDCIRKMYKYEGLTSFWKGIIPPILAETPKRAVKVNQRFLHLSSIKNCFYLIHPHPHL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GEZM01100110
EMBL· GenBank· DDBJ
JAV53013.1
EMBL· GenBank· DDBJ
Transcribed RNA

Similar Proteins

Disclaimer

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