A0A1Y1JV98 · A0A1Y1JV98_PHOPY
- ProteinMitochondrial 2-oxodicarboxylate carrier
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids116 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle.
Catalytic activity
- 2-oxoadipate(in) + 2-oxoglutarate(out) = 2-oxoadipate(out) + 2-oxoglutarate(in)2-oxoadipate (in)CHEBI:57499
+ 2-oxoglutarate (out)CHEBI:16810= 2-oxoadipate (out)CHEBI:57499+ 2-oxoglutarate (in)CHEBI:16810 - 2-oxoheptanedioate(in) + 2-oxoglutarate(out) = 2-oxoheptanedioate(out) + 2-oxoglutarate(in)
- L-2-aminoadipate(in) + 2-oxoglutarate(out) = L-2-aminoadipate(out) + 2-oxoglutarate(in)
- citrate(in) + 2-oxoglutarate(out) = citrate(out) + 2-oxoglutarate(in)
- glutarate(in) + 2-oxoglutarate(out) = glutarate(out) + 2-oxoglutarate(in)
- heptanedioate(in) + 2-oxoglutarate(out) = heptanedioate(out) + 2-oxoglutarate(in)
- hexanedioate(in) + 2-oxoglutarate(out) = hexanedioate(out) + 2-oxoglutarate(in)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMitochondrial 2-oxodicarboxylate carrier
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Elateriformia > Elateroidea > Lampyridae > Lampyrinae > Photinus
Accessions
- Primary accessionA0A1Y1JV98
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Keywords
- Cellular component
Structure
Sequence
- Sequence statusComplete
- Length116
- Mass (Da)13,075
- Last updated2017-08-30 v1
- Checksum2FDA22F243778913
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GEZM01100110 EMBL· GenBank· DDBJ | JAV53013.1 EMBL· GenBank· DDBJ | Transcribed RNA |