A0A1Y1JG74 · A0A1Y1JG74_PLAGO

  • Protein
    tRNA (guanine(37)-N1)-methyltransferase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

1748100200300400500600700
TypeIDPosition(s)Description
Binding site416S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site454-455S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site481-482S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site650S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial matrix
Cellular Componentnucleus
Molecular FunctiontRNA (guanine(37)-N1)-methyltransferase activity
Biological ProcesstRNA methylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA (guanine(37)-N1)-methyltransferase
  • EC number
  • Alternative names
    • M1G-methyltransferase
    • tRNA [GM37] methyltransferase
    • tRNA methyltransferase 5 homolog

Gene names

    • ORF names
      PGO_071220

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • ATCC 30045
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Plasmodium)

Accessions

  • Primary accession
    A0A1Y1JG74

Proteomes

Subcellular Location

Mitochondrion matrix
Nucleus
Cytoplasm
Note: Predominantly in the mitochondria and in the nucleus.

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-20
ChainPRO_501262095121-748tRNA (guanine37-N1)-methyltransferase

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain327-743SAM-dependent methyltransferase TRM5/TYW2-type

Sequence similarities

Belongs to the TRM5 / TYW2 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    748
  • Mass (Da)
    87,552
  • Last updated
    2017-08-30 v1
  • Checksum
    7793B9EADA689BE0
MFIRILYFLWILQHFAYVASLRKKGNFLHAFVKMNNPVNIKNLRDVKEKVKYEKKTHCLVLKKSKTNTILKNKYTKCWLMNVFKFPSVLKFVEYQKALIDSGVYNKELMSLIHTYLEKLEVGTRSMKNHASGLTHDQTIDMVKCETADVLKCETDDMVKYATIGQIGDHATDAVINAAGIDEGELRLIPLNEHFNKTLHELMEREGKGIMNGIDISPDEGEFQSDEEKKESASLRRERKYWNLINNEENNIKKEKYQMLKDVNKWPEDSILNDSSNRMKYLTELFYLIKKEDIKLSVIRLEFGYDNMNTSEILKKIFPSGNEIIHKYEMIGHIAHLNFCEKFEDYKKVIAEIILDKNKSIKTVINKKEMLNNVHRTFNMELLAGEKNYLTMLKENDIKIKLNYELIYWNSKLKKERDRIYDLVKKNSIIIDMFGGVGIFSLHLSKKNCLCFSNDINEHAYNYMNINVKLNKRKNILTYNLDATAFIDMLILLNLFSNDASTLTIHLNEQNIKNISLDFINSVHEQTNDNIKKKKSATTGTSNKTPDLVSEKKDAYHDVLDKKIKITSGDTNKFADEQDNNRYICHKDGLEPIHDVQKISQNSLSPQEERASCQLFIKDDAEKAINGELKNDLHKVEINLKHYGDIHVLMNLPQTAFKFLDVFRKIKNIYSVHKTDTQDKYVKDKMRNVFIHCYYFSKPEFFYEDAERNIRLQLKGIPREMKITEIRKVSPSKLMYVVEFNLKDIVGTE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BDQF01000008
EMBL· GenBank· DDBJ
GAW80207.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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