A0A1Y0SWV5 · A0A1Y0SWV5_MYCIT

Function

function

The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

Catalytic activity

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site94Nucleophile
Binding site128substrate
Active site194

GO annotations

AspectTerm
Molecular Functioncarbon-nitrogen ligase activity on lipid II
Molecular Functionglutaminase activity
Biological Processcell wall organization
Biological Processcobalamin biosynthetic process
Biological Processglutamine metabolic process
Biological Processpeptidoglycan biosynthetic process
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD
  • EC number
  • Alternative names
    • Lipid II isoglutaminyl synthase glutaminase subunit
      (EC:3.5.1.2
      ) . EC:3.5.1.2 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      cobQ2
    • Synonyms
      gatD
    • ORF names
      MYCOZU2_00358

Organism names

Accessions

  • Primary accession
    A0A1Y0SWV5

Proteomes

Interaction

Subunit

Forms a heterodimer with MurT.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the CobB/CobQ family. GatD subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    235
  • Mass (Da)
    24,602
  • Last updated
    2017-10-25 v1
  • Checksum
    F86995B197ED46FF
MADSTVRIGLVLPDVMGTYGDGGNALVLRQRLLLRGIPAEIVEITLADPVPESLDLYTLGGAEDYAQRLATRHLVKHPGLQRAAQRGAPVLAICAAVQVLGHWYETSAGQRVDGVGMLDATTSPQAARTIGELATRPLLAGLTERLTGFENHRGGTVLGPSASPLGAVVKGAGNRSGDGFDGVVQGSVIATYMHGPCLARNPQLADLLLGSVVGELPPLPMPEVDLLRRERLAAR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP015267
EMBL· GenBank· DDBJ
ASL12823.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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