A0A1Y0N6U5 · A0A1Y0N6U5_9BURK

  • Protein
    dITP/XTP pyrophosphatase
  • Gene
    rdgB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site7-12substrate
Active site68Proton acceptor
Binding site68Mg2+ (UniProtKB | ChEBI)
Binding site69substrate
Binding site154-157substrate
Binding site177substrate
Binding site182-183substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Name
      rdgB
    • ORF names
      AEP_01520

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • AEP1-3
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Comamonadaceae > Curvibacter

Accessions

  • Primary accession
    A0A1Y0N6U5

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    201
  • Mass (Da)
    21,299
  • Last updated
    2017-08-30 v1
  • MD5 Checksum
    3556C1C8D14DCA3F0775A7248295D9D4
MKIVLASNNQGKLAELNAMFAPLGCELVRQGDLGVPESPEPFRTFIENALAKARNAAQHTGLPALADDAGLCVDAFGGLPGVDTAYYATQFGYAKGDDNNVKALLEQMKDVTNRRAVLVSTLVAVRSVDDPEPLVAVGRVVGQIAPEPVGSNGFGFDPVMWIPEFGQTFAQLPVEVKNAHSHRGRAAAAMATLIRSNWLGA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP015698
EMBL· GenBank· DDBJ
ARV18467.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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