A0A1Y0AWP9 · A0A1Y0AWP9_TENMO

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Tenebrionidae > Tenebrio

Accessions

  • Primary accession
    A0A1Y0AWP9

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane38-58Helical
Transmembrane79-101Helical
Transmembrane113-136Helical
Transmembrane171-189Helical
Transmembrane209-231Helical
Transmembrane260-283Helical
Transmembrane303-320Helical
Transmembrane327-346Helical
Transmembrane352-373Helical
Transmembrane385-408Helical
Transmembrane414-437Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-21Disordered
Domain40-441Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    506
  • Mass (Da)
    56,522
  • Last updated
    2017-08-30 v1
  • Checksum
    6365765525B18135
MEGGPNIQEAENLIDSSTDEEERSEGCGYKCCDPRGSLHRFVALIFMCFLGFGSYFCYDNPAALQDQIKRDLNITTTQYTLLYSMYSWPNVVLCFVGGFLIDRVFGIRLGTNIYMGLTLLGQVVFASGVLFNTFWITIMGRFIFGIGAESLAVAQNNYAVLWFKGKELNMVFGLQLSFARIGSTVNFWVMESIYAWVNQEYKGYQGLGIVLFVATSTCIFSMLCALILGWMDKRAETILRRHESTSGEVVRFTDVVQFKLTFWLITVICVAYYVAIFPFIGLGKDFFTSRFHMTNQQANNVNSIVYLLSGIASPLLGFLIDMVGKNVLWITVAISTTIGCHCLLAFTMVDPYVGMVLMGVAYSCLASSLWPLVSLIIPEHQLGTAYGVCQSVQNLGLAVFNIVAGTIVEHYGYTWVEVFFIGSLSVALATTIILWLLDLWQDGILNMTPKKRLARLQLIDVGSEKDVLQDDEADTSYGTMQPSTDFEIRNRYLSRIGAPVSDSIEE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY921821
EMBL· GenBank· DDBJ
ART29410.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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