A0A1X9YK79 · A0A1X9YK79_9SPHN
- ProteinGlycerol kinase
- GeneglpK
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids495 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
Catalytic activity
- ATP + glycerol = ADP + H+ + sn-glycerol 3-phosphate
Activity regulation
Inhibited by fructose 1,6-bisphosphate (FBP).
Pathway
Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 14 | ADP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 14 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 14 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 15 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 16 | ATP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 18 | ADP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 84 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 84 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 85 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 85 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 136 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 136 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 245 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 245 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 246 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 267 | ADP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 267 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 310 | ADP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 310 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 411 | ADP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 411 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 415 | ADP (UniProtKB | ChEBI) | ||||
Sequence: N |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | glycerol kinase activity | |
Biological Process | glycerol catabolic process | |
Biological Process | glycerol-3-phosphate metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlycerol kinase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Sphingomonadales > Sphingomonadaceae > Sphingomonas
Accessions
- Primary accessionA0A1X9YK79
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-252 | Carbohydrate kinase FGGY N-terminal | ||||
Sequence: ILAIDQGTTSTRSIIFDAQARVLATAQAEFAQHYPQDGWVEHDAEDIWRDTLATAREAIAKAALNASDIAAIGITNQRETTVLWDRATGTPLHKAIVWQDRRTADHCAALKAAGHEALVRARTGLLIDPYFSATKLGWLLDHVPGARARAERGELAFGTIDSFLLWRMTGGRVHATDATNASRTMLFDIHRQIWCEELLDLFGIPTSLLPEVRDSSGLFGLCDPDLFGAAIPIAGIAGDQQAALVG | ||||||
Domain | 262-450 | Carbohydrate kinase FGGY C-terminal | ||||
Sequence: KATYGTGCFMLLNTGEQAVASDKRLLTTTAYRLEGKVAYAVEGSIFVAGAAIKWLRDGLGLITHASQTDDLATRVADNGGVYMVPAFVGLGAPHWDAHARGLICGLTLNSSAAHVARAALESIGYQTADLVTAMMEDGAAQPSALRVDGGMSANDWLCQFLADILEIPVERPANLETTALGAAFLAGMG |
Sequence similarities
Belongs to the FGGY kinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length495
- Mass (Da)52,703
- Last updated2017-08-30 v1
- ChecksumA302EDF8831F2AA5
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP016306 EMBL· GenBank· DDBJ | ARS29131.1 EMBL· GenBank· DDBJ | Genomic DNA |