A0A1X6Z7H6 · A0A1X6Z7H6_9RHOB

  • Protein
    dITP/XTP pyrophosphatase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site14-19substrate
Binding site46Mg2+ (UniProtKB | ChEBI)
Active site75Proton acceptor
Binding site75Mg2+ (UniProtKB | ChEBI)
Binding site76substrate
Binding site161-164substrate
Binding site184substrate
Binding site189-190substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      RUM8411_01950

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CECT 8411
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rhodobacterales > Roseobacteraceae > Ruegeria

Accessions

  • Primary accession
    A0A1X6Z7H6

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    204
  • Mass (Da)
    22,145
  • Last updated
    2017-07-05 v1
  • Checksum
    8A7880E97D2D4BCC
MTRKFDGDRLLVATHNKGKLEEMAHLLSPFGVSVVGAGEMNLPEPEETEDTFVGNARIKAHAAAKATGLPALSDDSGITIDALDGAPGVYTADWAETGNGRDFLMAMTRAYTELEAKGAAHPRTAQFRSTLVLAWPDGHDEVFEGIAPGHLVWPIRGEGGFGYDPMFVPEGHDITFAEMDRWEKNKISHRGRAVDMFVKGCFDG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FWFP01000005
EMBL· GenBank· DDBJ
SLN43186.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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