A0A1X6NPU2 · A0A1X6NPU2_PORUM

Function

function

Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentHolliday junction resolvase complex
Cellular Componentnucleus
Molecular Function3'-flap endonuclease activity
Molecular Functioncrossover junction DNA endonuclease activity
Molecular FunctionDNA binding
Molecular Functionmetal ion binding
Biological ProcessDNA catabolic process
Biological Processdouble-strand break repair via break-induced replication
Biological Processmitotic intra-S DNA damage checkpoint signaling
Biological Processresolution of meiotic recombination intermediates

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Crossover junction endonuclease MUS81
  • EC number

Gene names

    • ORF names
      BU14_0712s0001

Organism names

Accessions

  • Primary accession
    A0A1X6NPU2

Proteomes

Subcellular Location

Keywords

  • Cellular component

Interaction

Subunit

Interacts with EME1.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain27-139ERCC4

Sequence similarities

Belongs to the XPF family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    185
  • Mass (Da)
    19,779
  • Last updated
    2017-07-05 v1
  • Checksum
    95A23F23A3F6AD04
MPWASMPVELQFPFPMTPDGALVAEVYLVEDDREMVGVGPSRDALPSRLRVNPGLANRVERRRLPTGDAVFVAHVTAAGEAPVAGAPQTGTKIVLDQLIERQTAADMVASLRDGRLRQQTYNMAATGCKGLVLIVKGDLDAATENGANVREEAKNVLAELTVSSNFVFKNTADLTETAALFSSLV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KV919233
EMBL· GenBank· DDBJ
OSX70602.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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