A0A1X6NPU2 · A0A1X6NPU2_PORUM
- ProteinCrossover junction endonuclease MUS81
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids185 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Cofactor
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | Holliday junction resolvase complex | |
Cellular Component | nucleus | |
Molecular Function | 3'-flap endonuclease activity | |
Molecular Function | crossover junction DNA endonuclease activity | |
Molecular Function | DNA binding | |
Molecular Function | metal ion binding | |
Biological Process | DNA catabolic process | |
Biological Process | double-strand break repair via break-induced replication | |
Biological Process | mitotic intra-S DNA damage checkpoint signaling | |
Biological Process | resolution of meiotic recombination intermediates |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCrossover junction endonuclease MUS81
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Rhodophyta > Bangiophyceae > Bangiales > Bangiaceae > Porphyra
Accessions
- Primary accessionA0A1X6NPU2
Proteomes
Subcellular Location
Interaction
Subunit
Interacts with EME1.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 27-139 | ERCC4 | ||||
Sequence: YLVEDDREMVGVGPSRDALPSRLRVNPGLANRVERRRLPTGDAVFVAHVTAAGEAPVAGAPQTGTKIVLDQLIERQTAADMVASLRDGRLRQQTYNMAATGCKGLVLIVKGDL |
Sequence similarities
Belongs to the XPF family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length185
- Mass (Da)19,779
- Last updated2017-07-05 v1
- Checksum95A23F23A3F6AD04
Keywords
- Technical term