A0A1X4HC41 · A0A1X4HC41_HALEZ

Function

function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.
One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site119(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site123-125(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Site227Plays an important role in substrate specificity
Binding site353-355(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioncobalt ion binding
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionmethyltransferase activity
Molecular Functionpyridoxal phosphate binding
Molecular Functionserine binding
Molecular Functionzinc ion binding
Biological Processfolic acid metabolic process
Biological Processglycine biosynthetic process from serine
Biological ProcessL-serine catabolic process
Biological Processmethylation
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine hydroxymethyltransferase
  • EC number
  • Short names
    SHMT
    ; Serine methylase

Gene names

    • Name
      glyA
    • ORF names
      B9H04_00680

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 17463
  • Taxonomic lineage
    Archaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Haloferacaceae > Halorubrum

Accessions

  • Primary accession
    A0A1X4HC41

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue228N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-384Serine hydroxymethyltransferase-like

Sequence similarities

Belongs to the SHMT family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    415
  • Mass (Da)
    44,444
  • Last updated
    2017-07-05 v1
  • Checksum
    E08BAFAB73AD9555
MDHEHVREVDPAVADALAGERDRQEQTLAMIASENHVSEAVLEAQGSVLTNKYAEGYPGSRYYAGCEYADEVEELAIERAKELWGADHVNVQPHSGTQANQAVYYSVLEPGDKILSLKLNDGGHLSHGHPANFTGQLYEVEQYEVDPETGYIDYEGLREVAEEFDPDIVVSGYSAYPRAVEWEKIQAAADAVDAYHLADIAHITGLVAAGVHPSPVGVADFVTGSTHKTIRAGRGGIVMCDAEFADDIDSAVFPGGQGGPLMHNVAGKAVGFKEALEPEFEEYAQQVVDNAEVLAETLQEHGLSLVSGGTDNHLVLADLRDSHPDLSGGDAEDALAAANIVLNGNTVPGETRSAFDPSGIRAGTAGLTTRGFDADAIEEVGDLIYRVVDDVDSDDVIYEVGERVVELCEAHPLYE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NEDJ01000001
EMBL· GenBank· DDBJ
OSP11252.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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