A0A1X2GZI5 · A0A1X2GZI5_SYNRA
- ProteinTransketolase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids677 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
Catalytic activity
- D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate
Cofactor
Protein has several cofactor binding sites:
Ca2+ (UniProtKB | Rhea| CHEBI:29108 )
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Co2+ (UniProtKB | Rhea| CHEBI:48828 )
Note: Binds 1 Mg2+ ion per subunit. Can also utilize other divalent metal cations, such as Ca2+, Mn2+ and Co2+.
Note: Binds 1 thiamine pyrophosphate per subunit.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 28 | Important for catalytic activity | ||||
Sequence: H | ||||||
Site | 262 | Important for catalytic activity | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | metal ion binding | |
Molecular Function | transketolase activity | |
Biological Process | pentose-phosphate shunt |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTransketolase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Mucoromycotina > Mucoromycetes > Mucorales > Syncephalastraceae > Syncephalastrum
Accessions
- Primary accessionA0A1X2GZI5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 354-530 | Transketolase-like pyrimidine-binding | ||||
Sequence: VATRKLSEGVLTALSEIIPDLVGGSADLTGSNLTRWKKAVDFQHPSTGLGDYSGRYVRYGVREHAMFAIMNGLAAYGGIIPFGGTFLNFLTYGWGAARLSALSHLRVIYVMTHDSIGLGEDGPTHQPIETLTISRATPNMLTFRPADGNEVSGTYLVAIENAHRPSVIALSRQNLPQ |
Sequence similarities
Belongs to the transketolase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length677
- Mass (Da)72,736
- Last updated2017-07-05 v1
- Checksum4CE7F6ECEEE4B498
Keywords
- Technical term