A0A1X2DXF9 · A0A1X2DXF9_9MYCO
- ProteinProteasome subunit beta
- GeneprcB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids296 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
Catalytic activity
Activity regulation
The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.
Pathway
Protein degradation; proteasomal Pup-dependent pathway.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 59 | Nucleophile | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | proteasome core complex, beta-subunit complex | |
Molecular Function | threonine-type endopeptidase activity | |
Biological Process | modification-dependent protein catabolic process | |
Biological Process | proteasomal protein catabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProteasome subunit beta
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium
Accessions
- Primary accessionA0A1X2DXF9
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for propeptide, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Propeptide | PRO_5010892497 | 1-58 | Removed in mature form; by autocatalysis | ||
Chain | PRO_5023420272 | 59-296 | Proteasome subunit beta | ||
Keywords
- PTM
Interaction
Subunit
The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length296
- Mass (Da)31,098
- Last updated2017-07-05 v1
- MD5 Checksum2187C88C7B8E229D442179B0F3E944A0
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LQPV01000019 EMBL· GenBank· DDBJ | ORW92877.1 EMBL· GenBank· DDBJ | Genomic DNA |