A0A1X2A556 · A0A1X2A556_9MYCO
- ProteinUridylate kinase
- GenepyrH
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids249 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reversible phosphorylation of UMP to UDP.
Catalytic activity
- UMP + ATP = UDP + ADP
Activity regulation
Inhibited by UTP.
Pathway
Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 24-27 | ATP (UniProtKB | ChEBI) | ||||
Sequence: KLGG | ||||||
Binding site | 65 | UMP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 66 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 70 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 85 | UMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 146-153 | UMP (UniProtKB | ChEBI) | ||||
Sequence: MGLPYFST | ||||||
Binding site | 179 | ATP (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 182 | ATP (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | UMP kinase activity | |
Biological Process | 'de novo' CTP biosynthetic process | |
Biological Process | phosphorylation | |
Biological Process | UDP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUridylate kinase
- EC number
- Short namesUK
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium > Mycobacterium simiae complex
Accessions
- Primary accessionA0A1X2A556
Proteomes
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 20-227 | Aspartate/glutamate/uridylate kinase | ||||
Sequence: RVLLKLGGEMFGGGQVGLDPDVVAQVARQIAEVVRGGVQVAVVIGGGNFFRGAQLQQRGMERTRSDYMGMLGTVMNSLALQDFLEKEGIVTRVQTAITMGQVAEPYLPLRAVRHLEKGRVVIFGAGMGLPYFSTDTTAAQRALEIGAEVVLMAKAVDGVFSADPRLNPEAELITAISHREVIDRGLRVADATAFSLCMDNGMPILVFN |
Sequence similarities
Belongs to the UMP kinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length249
- Mass (Da)26,633
- Last updated2017-07-05 v1
- Checksum8D72002DCD36C691