A0A1X1TKX5 · A0A1X1TKX5_9MYCO

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site8-13substrate
Active site73Proton acceptor
Binding site73Mg2+ (UniProtKB | ChEBI)
Binding site74substrate
Binding site155-158substrate
Binding site178substrate
Binding site183-184substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Name
      rdgB
    • ORF names
      AWC01_01655
      , MDOR_27020

Organism names

  • Taxonomic identifier
  • Strains
    • DSM 44339
    • JCM 12405
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycolicibacterium

Accessions

  • Primary accession
    A0A1X1TKX5

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    200
  • Mass (Da)
    20,882
  • Last updated
    2017-07-05 v1
  • Checksum
    7B091A2740387C00
MADVLVASRNRKKLAELRRVLDAAGVSGLTLLSLDDVAPFDEAPETGATFEENALAKARDGFRASGIATVADDSGLEVDALNGMPGVLSARWAGAHGGDDANTALLLAQLRDVPAARRGASFVSACALVAGTREVVVRGVWRGVITREPRGSGGFGYDPVFLPEHFDRTAAELTPAEKDAASHRGRALAQLVPALRALGR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP022605
EMBL· GenBank· DDBJ
BBZ08533.1
EMBL· GenBank· DDBJ
Genomic DNA
LQOS01000008
EMBL· GenBank· DDBJ
ORV45227.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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