A0A1X1KKB1 · A0A1X1KKB1_STRMT

  • Protein
    3-dehydroquinate dehydratase
  • Gene
    aroD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site63-dehydroquinate (UniProtKB | ChEBI)
Binding site30-323-dehydroquinate (UniProtKB | ChEBI)
Binding site623-dehydroquinate (UniProtKB | ChEBI)
Active site118Proton donor/acceptor
Active site143Schiff-base intermediate with substrate
Binding site1863-dehydroquinate (UniProtKB | ChEBI)
Binding site2053-dehydroquinate (UniProtKB | ChEBI)
Binding site2093-dehydroquinate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function3-dehydroquinate dehydratase activity
Biological Process3,4-dihydroxybenzoate biosynthetic process
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-dehydroquinate dehydratase
  • EC number
  • Short names
    3-dehydroquinase
  • Alternative names
    • Type I DHQase
    • Type I dehydroquinase
      (DHQ1
      )

Gene names

    • Name
      aroD
    • ORF names
      B7697_03280
      , D8855_09690

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • RH_17024_08
    • BCA12
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus

Accessions

  • Primary accession
    A0A1X1KKB1

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the type-I 3-dehydroquinase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    225
  • Mass (Da)
    25,704
  • Last updated
    2017-07-05 v1
  • MD5 Checksum
    55C24FAD9A504A7AF3CFF196A847ECC9
MKLIVSVMPRSLEEAQALDATRYLDADIIEWRADYLPKEAILQVAPAIFEKFAGRELVFTLRTRSEGGEIDLSPEEYIHLIKEVAQLYQPDYIDFEYYSYKDVFEEMLDFPNLVLSYHNFQETPENMMEILSELTSLNPKLVKVAVMAHTEQDVLDLMNYTRGFKILNPEQEYVTISMGKVGKVSRITADVTGSSWSFASLDEASAPGQISLANMKKIREILDEA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NCVI01000018
EMBL· GenBank· DDBJ
ORO99883.1
EMBL· GenBank· DDBJ
Genomic DNA
RJNR01000027
EMBL· GenBank· DDBJ
RSI78203.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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