A0A1X0YCW1 · A0A1X0YCW1_9BACT

Function

function

Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis.

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functionmetal ion binding
Molecular Functionphosphorelay sensor kinase activity
Biological Processthiamine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    histidine kinase
  • EC number
  • Alternative names
    • Thiamine pyrimidine synthase

Gene names

    • ORF names
      B5V00_02410

Organism names

  • Taxonomic identifier
  • Strain
    • EPR-M
  • Taxonomic lineage
    Bacteria > Thermodesulfobacteriota > Desulfuromonadia > Desulfuromonadales > Geothermobacteraceae > Geothermobacter

Accessions

  • Primary accession
    A0A1X0YCW1

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane331-351Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-27
ChainPRO_501307222328-742histidine kinase

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for coiled coil, domain.

Type
IDPosition(s)Description
Coiled coil364-391
Domain526-742Histidine kinase

Sequence similarities

Belongs to the NMT1/THI5 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    742
  • Mass (Da)
    83,007
  • Last updated
    2017-07-05 v1
  • MD5 Checksum
    BDFC27A29D7779064156624AB5162927
MSLLNAFFKILIPCVLSVPFCLGTLHAAEPETVVLQLKWRHQFQFAGYYAAMAKGFYRAEGLRVEVREGSPGQDIVQELVSGRAQYMVHNSTALLACAGGAPLVALAVVFQQSPLALIAREDSGINSLADLAGKPVMLSPTTEPELVAMLRAEGFNLNQFQFQLLPHSGNPEDLVSGRVAAMAGYLTDLPFYLEQRNVRPVVIRPSHYGINFYGDTLFTSRHELEDHPQQVAAFRRASLKGWDYAMQHPGEIVELILRRYPGRLNRGQLLNEAEQMRRLILPDLVEIGHMNPSRWQHIAQVFSDAGMLPGRLDLGMFLYHPDRPGGGFPGWLAPVSGVFFAILLLLLLFNWRLRHAVTHRTVALDRVNRNLQQMLALKEKAEQDLVVKEQQLRTIVESVLQGLLIVAEDRILFANRAAAEIVGCDTAEELLAMGWIDNFIAPHEHTRLHAYLQDRLSGKNLPESYVFEGVRRDGSRGWVENRAVRIEWQGRPAVLVSMTDVTERVRLREESIRAAQLASLGELAASVAHEINNPINGIINYAQILKNALVHEEKWCDIAGRILKESDRVATIVAGLLSFSRSGAAERKTIRIHDILEDTLVLVRTQLQKDGICLDLDIPETLPLVRVVPQQIQQVYLNLINNARYALNQKYLHPCAEKRLQISCQLQDDSCLATIFYDQGIGIADQDLERVLAPFFTTKPGKEGAGLGLSISCRIMQDHGGDIRIESRNGEFTRVVTILPVN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NAAD01000002
EMBL· GenBank· DDBJ
ORJ62923.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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