A0A1X0YA85 · A0A1X0YA85_9BACT

Function

function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site35[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site36[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site101[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site130[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioniron ion binding
Molecular FunctionNAD binding
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Molecular FunctionNADH:ubiquinone reductase (non-electrogenic) activity
Molecular Functionquinone binding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 3 domains:

  • Recommended name
    NADH-quinone oxidoreductase subunit B
  • EC number
  • Alternative names
    • NADH dehydrogenase I subunit B
    • NDH-1 subunit B
  • Recommended name
    NADH-quinone oxidoreductase subunit C
  • Alternative names
    • NADH dehydrogenase I subunit C
    • NDH-1 subunit C
  • Recommended name
    NADH-quinone oxidoreductase subunit D
  • Alternative names
    • NADH dehydrogenase I subunit D
    • NDH-1 subunit D

Gene names

    • Name
      nuoC
    • Synonyms
      nuoB
      , nuoD
    • ORF names
      B5V00_05150

Organism names

  • Taxonomic identifier
  • Strain
    • EPR-M
  • Taxonomic lineage
    Bacteria > Thermodesulfobacteriota > Desulfuromonadia > Desulfuromonadales > Geothermobacteraceae > Geothermobacter

Accessions

  • Primary accession
    A0A1X0YA85

Proteomes

Subcellular Location

Cell inner membrane
; Peripheral membrane protein
Cell membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Keywords

Interaction

Subunit

NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
NDH-1 is composed of about 13 different subunits. Subunits NuoBCD, E, F, and G constitute the peripheral sector of the complex.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain35-143NADH:ubiquinone oxidoreductase-like 20kDa subunit
Region160-203Disordered
Domain252-377NADH:ubiquinone oxidoreductase 30kDa subunit
Domain524-794NADH-quinone oxidoreductase subunit D

Sequence similarities

Belongs to the complex I 20 kDa subunit family.
Belongs to the complex I 30 kDa subunit family.
Belongs to the complex I 49 kDa subunit family.
In the C-terminal section; belongs to the complex I 49 kDa subunit family.
In the N-terminal section; belongs to the complex I 20 kDa subunit family.
In the central section; belongs to the complex I 30 kDa subunit family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    794
  • Mass (Da)
    90,658
  • Last updated
    2017-07-05 v1
  • Checksum
    9AC1B5AB210F3167
MSEEIPDNVVLTTLDDVINWSRSNSIWPMFFGLSCCFVEMTTSLTPRFDLARFGAEVLRGTPREADLMVISGTPFKKMGPSILRLYEQMTNPKWVIAMGSCANSGGMYDSYSVIQGIHQILPVDVYIPGCPPRPEAFMQGIMLLQEKIRSKEKPTRLVLGMNGGSEGTTEPILVDGHSKSRDPRGPGYGNAPLRGSQLQHPHFHPSRADNMWLPPQPRAAFPASTHNLRRALKERFGETVQEEDARDMPTLVVAPEQLVELMTFLRQDAPIRYRRLEDLTAVDESDRRQQTGHRFTLTAHLLSFDEPGYLRVKAPLDGGWPEAPSLTGLWPSADWYEREIFDMFGIRFAGHPDLRRILMPDSWQGHPLRKEHPFRATEMDPYTRKTARQMEPRDGGDFFRGKPLAEDFEAMILNIGPHHPGTHGVLRLIALLDGEEIEDLDIDLGYHHRAAEKIGERQHWSQFIPYTDRIDYLSGVQNNLAYLHPLETMLGVEVPPRAETVRVMLCELFRIANHLVWLGTFAHDVGAMTPIFYCMESREKIFDIIEMITGGRMHPSWFRIGGLPKDLPEGWKSVVEAFTRDFDQRITELDKLLTNGPIFRKRTEDVGPVSRDEALDWGMSGPNLRACGFEWDLRRKMPYSGYQHYDFDIVTAAGGDCFARYLVRLKEMRESLKIVRQAAERMPAGRWMTDDYRYAYPQREDGLNDIESLIHHFCNVTRGPSVPRGEVYRAIESSKGECGYYLVSDGHTVPYRLRIRTPSFAHMQMVPMMSRGWLVADMITILGSIDFVLADLDR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NAAD01000004
EMBL· GenBank· DDBJ
ORJ62140.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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