A0A1X0YA85 · A0A1X0YA85_9BACT
- ProteinMultifunctional fusion protein
- GenenuoC
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids794 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic activity
- a quinone + NADH + 5 H+(in) = a quinol + NAD+ + 4 H+(out)
CHEBI:132124 + CHEBI:57945 + 5 H+ (in)CHEBI:15378= CHEBI:24646 + CHEBI:57540 + 4 H+ (out)CHEBI:15378
Cofactor
Note: Binds 1 [4Fe-4S] cluster.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 35 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 36 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 101 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 130 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | iron ion binding | |
Molecular Function | NAD binding | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Molecular Function | NADH:ubiquinone reductase (non-electrogenic) activity | |
Molecular Function | quinone binding |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameMultifunctional fusion protein
Including 3 domains:
- Recommended nameNADH-quinone oxidoreductase subunit B
- EC number
- Alternative names
- Recommended nameNADH-quinone oxidoreductase subunit C
- Alternative names
- Recommended nameNADH-quinone oxidoreductase subunit D
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Thermodesulfobacteriota > Desulfuromonadia > Desulfuromonadales > Geothermobacteraceae > Geothermobacter
Accessions
- Primary accessionA0A1X0YA85
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Peripheral membrane protein
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
NDH-1 is composed of about 13 different subunits. Subunits NuoBCD, E, F, and G constitute the peripheral sector of the complex.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 35-143 | NADH:ubiquinone oxidoreductase-like 20kDa subunit | |||
Region | 160-203 | Disordered | |||
Domain | 252-377 | NADH:ubiquinone oxidoreductase 30kDa subunit | |||
Domain | 524-794 | NADH-quinone oxidoreductase subunit D | |||
Sequence similarities
Belongs to the complex I 20 kDa subunit family.
Belongs to the complex I 30 kDa subunit family.
Belongs to the complex I 49 kDa subunit family.
In the C-terminal section; belongs to the complex I 49 kDa subunit family.
In the N-terminal section; belongs to the complex I 20 kDa subunit family.
In the central section; belongs to the complex I 30 kDa subunit family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length794
- Mass (Da)90,658
- Last updated2017-07-05 v1
- Checksum9AC1B5AB210F3167
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
NAAD01000004 EMBL· GenBank· DDBJ | ORJ62140.1 EMBL· GenBank· DDBJ | Genomic DNA |