A0A1X0WEQ4 · A0A1X0WEQ4_9GAMM

  • Protein
    Diaminopimelate decarboxylase
  • Gene
    lysA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site230pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site271-274pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site274substrate
Binding site310substrate
Binding site314substrate
Active site345Proton donor
Binding site346substrate
Binding site381pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site381substrate

GO annotations

AspectTerm
Molecular Functiondiaminopimelate decarboxylase activity
Molecular Functionpyridoxal phosphate binding
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Diaminopimelate decarboxylase
  • EC number
  • Short names
    DAP decarboxylase
    ; DAPDC

Gene names

    • Name
      lysA
    • ORF names
      BS640_11765

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • DSM 100043
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Yersiniaceae > Rouxiella

Accessions

  • Primary accession
    A0A1X0WEQ4

Proteomes

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue54N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain30-379Orn/DAP/Arg decarboxylase 2 C-terminal
Domain48-278Orn/DAP/Arg decarboxylase 2 N-terminal

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    423
  • Mass (Da)
    46,415
  • Last updated
    2017-07-05 v1
  • Checksum
    240195A6E370A6C2
MPFALNNNENALNSANLLSAVKAFGSPVWVYDAQVIEQRISQLRLFDVIRFAQKASSNIHILRLMREQGVKVDSVSLGEIERALVAGFKPGYQPGEHSEIVFTADVLDPATLARVTELSIPVNAGSIDMLEQIGQQKPGHPVWLRVNPGFGHGHSQKTNTGGENSKHGIWFGDLPLALEKIRAYQLKLVGIHMHIGSGVDYQHLEQVCDTMVRQVIELGHDIEAISAGGGLSIPYQFGGESIDTDHYYGLWNRAREQIAAHLGHPVSLEIEPGRFLVAESGVLVAQIRAVKSMGSRHYVLVDAGFSDLMRPSMYGSYHHISVLPADGRDLSEQPQRESVIAGPLCESGDVFTQQAGGGVETRVLPEADINDYLVFHDTGAYGASMSSNYNSRPLIAEVLFENGVPRLIRRRQTIEELLALENI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MRWE01000017
EMBL· GenBank· DDBJ
ORJ25288.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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