A0A1X0P6H3 · A0A1X0P6H3_9TRYP

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-.
    EC:3.4.24.36 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

1974100200300400500600700800900
Type
IDPosition(s)Description
Binding site293Zn2+ (UniProtKB | ChEBI); catalytic
Active site294
Binding site297Zn2+ (UniProtKB | ChEBI); catalytic
Binding site358Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmembrane
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological Processcell adhesion
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    leishmanolysin
  • EC number
  • Alternative names
    • Cell surface protease
    • Major surface glycoprotein
    • Protein gp63

Gene names

    • ORF names
      TM35_000044470

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Edinburgh
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Trypanosoma

Accessions

  • Primary accession
    A0A1X0P6H3

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane924-950Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-16
ChainPRO_501228122917-974leishmanolysin

Keywords

Family & Domains

Features

Showing features for compositional bias, region.

Type
IDPosition(s)Description
Compositional bias42-56Polar residues
Region42-119Disordered
Compositional bias57-87Basic and acidic residues
Compositional bias89-104Basic residues
Compositional bias105-119Basic and acidic residues

Sequence similarities

Belongs to the peptidase M8 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    974
  • Mass (Da)
    107,474
  • Last updated
    2017-07-05 v1
  • Checksum
    B52811DDA6C3E837
MQLLMLLLFFVPETMAIRKVEHHCIHAESRVQRLIIGNTNTSAYSHESNNNNKRKSNNNNDNEEEEKEGLNTGYEHQKSDNARKSLQGSKSKSRVKRFNIARRNKKLSNKKDNDGKIKLKNGTETWEPLRIVVDTSLLVDPSKICTAVGQVRTDFMGSTHTCLSQDIMTLEKVWIIENVALPLAIYRVQQLLNVNPLQGPLLVTKNICGPDVTIPESHSTVGVLDADMILYAHAGGMDNSATPGVMGTIAWAAHCELNEAGRPIVGHINFVPSFIQWFVSGWEYEYYVRIIIHELLHALGFTPTFIDPMVNISERRGKSVHLVTAPAVIAAAQTHLSCPTLDGVELEDEGGSGTAWTHWERRGWMDELMAGIPSRAAISALTLAFFSSLNLYTVNMEYNETMSWSYHAGCPFLEERCVANAQRMGFEWCNDTSTAQLCTFDRLAVGLCNTGLVPNLPPYFQYFPAEPMRAGVTPLMDYCPIVVGYGNRQCTQPVESTSDDALYGFYFGTQSRCVPTHNMVKKGYTIDDNNPRCLMVRCRLGKQVEVFVGSYWLECPADGSAGVITIPAYTGYNGEIHCERAEKVCSSTLFYNPDSAASASTVDEGPLREYALDVILLLNTTVSGNKSNVMHTLGRMATVEPGMFFILLQEEITTLCKCKLGTSNIRILPEYASAAVVNGGIVVNFQLGLMIGAGSATIENMRNMYESKFMVNSVLSRIGAYITEEEKEEEGGIFTVTIASSEILPEAVIVDEITSLDQLVALGEIHLHCKGDLTGMPSLTDQKVITLLENAVRQDISQIILLTPNLIEVKHLQITGSTDLLITLTVYFPPVADGIGGNENILHLWEQLLMNSTTITITTTITSMPSPLPVLTSTVQFLSKGAPVSVTDNISSSSALSLFSADVSEVQPDSTGDSRCVVQFTGCFAVQIVILIILILIVLIMIVVFLKLCLCPKPKWRIQVETCELVVPLQEKYR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias42-56Polar residues
Compositional bias57-87Basic and acidic residues
Compositional bias89-104Basic residues
Compositional bias105-119Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NBCO01000004
EMBL· GenBank· DDBJ
ORC92233.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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